CADM2 - cell adhesion molecule 2 Gene

Also Known as NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 253559

About CADM2

Cytogenetic location: 3p12.1 Genomic coordinates (GRCh38): 3:84,958,989-86,074,429 (from NCBI)

This gene has 5 transcripts (splice variants), 273 orthologues and 14 paralogues. Biased expression in brain (RPKM 29.4), fat (RPKM 2.4) and 1 other tissue.

Summary

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with Other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

CADM2 Products (14)

mRNA Protein Name
NM_001167674.2 NP_001161146.1 cell adhesion molecule 2 isoform 1 precursor
NM_001167675.2 NP_001161147.1 cell adhesion molecule 2 isoform 2 precursor
NM_001256502.2 NP_001243431.1 cell adhesion molecule 2 isoform 4
NM_001256503.2 NP_001243432.1 cell adhesion molecule 2 isoform 4
NM_001256504.2 NP_001243433.1 cell adhesion molecule 2 isoform 5
NM_001256505.2 NP_001243434.1 cell adhesion molecule 2 isoform 5
NM_001375960.1 NP_001362889.1 cell adhesion molecule 2 isoform 6 precursor
NM_001375961.1 NP_001362890.1 cell adhesion molecule 2 isoform 7
NM_001375964.1 NP_001362893.1 cell adhesion molecule 2 isoform 8 precursor
NM_001375967.1 NP_001362896.1 cell adhesion molecule 2 isoform 9 precursor
NM_001375968.1 NP_001362897.1 cell adhesion molecule 2 isoform 10 precursor
NM_001381963.1 NP_001368892.1 cell adhesion molecule 2 isoform 11 precursor
NM_001381964.1 NP_001368893.1 cell adhesion molecule 2 isoform 1 precursor
NM_153184.4 NP_694854.2 cell adhesion molecule 2 isoform 3 precursor

CADM2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (27 - 109)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (140 - 210)

I-set

I-set: Immunoglobulin I-set domain (229 - 313)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
Protein Preferred Names Protein Names

cell adhesion molecule 2

  • immunoglobulin superfamily member 4D

Recombinant CADM2 Proteins

Cat. No. Product Name Accession Purity
HY-P75599 CADM2/IGSF4D Protein, Human (HEK293, His) Q8N3J6-2 (G30-D335) ≥ 95%, as determined by reducing SDS-PAGE.

CADM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811131 CADM2 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Cannabis Dependence

  • Marijuana Abuse

  • Cannabinoid Addiction

  • Cannabinoid Dependence

  • Cannabis Addiction
Hallucinogen Dependence

  • Hallucinogen Addiction
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01820 CADM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19414 Cadm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25906 Cadm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CADM2 VGNC VGNC:70674
Mus musculus CADM2 MGD MGI:2442722
Felis catus CADM2 VGNC VGNC:102609
Rattus norvegicus CADM2 RGD RGD:1305678
Canis familiaris CADM2 VGNC VGNC:38656
Bos taurus CADM2 VGNC VGNC:26695
Others CADM2 NCBI