Gdnf - glial cell derived neurotrophic factor Gene

Also Known as gndf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25453

Summary

Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study Parkinsonism and middle cerebral artery infarction. Biomarker of Parkinsonism and sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Gdnf Products (2)

mRNA Protein Name
NM_001401780.1 NP_001388709.1 glial cell line-derived neurotrophic factor isoform 2
NM_019139.2 NP_062012.2 glial cell line-derived neurotrophic factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glial cell-derived neurotrophic factor receptor binding IPI
IPI: Inferred from physical interaction
10545102 RGD
enables growth factor activity IDA
IDA: Inferred from direct assay
12595497 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9187648 RGD
enables receptor ligand activity IMP
IMP: Inferred from mutant phenotype
10545102 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
10545102 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17537984 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
22111653 RGD
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
IDA: Inferred from direct assay
17522159 RGD
involved in midbrain development IEP
IEP: Inferred from expression pattern
16650834 RGD
involved in negative regulation of glial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22251670 RGD
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
32428552 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21311297 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
32428552 RGD
involved in neuron differentiation IDA
IDA: Inferred from direct assay
15109990 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
17522159 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17537984 RGD
involved in positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
32428552 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
21311297 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
10545102 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
32428552 RGD
involved in regulation of ureteric bud formation IDA
IDA: Inferred from direct assay
19112489 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
16650834 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12595497 RGD
located in extracellular space IMP
IMP: Inferred from mutant phenotype
10545102 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
15709767 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glial cell line-derived neurotrophic factor

  • ATF

  • Glial cell line derived neutrophic factor

  • astrocyte-derived trophic factor

Recombinant Gdnf Proteins

Cat. No. Product Name Accession Purity
HY-P73075 GDNF Protein, Rat (sf9, His) Q07731-1 (S78-I211) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136832 Noribogaine hydrochloride 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111969 BT18 99.77% Unkown
HY-119910 (E)-Aminoquinol 99.70% Unkown
HY-163840 GFRα2/3-IN-1 Inhibitor / Unkown
HY-119910A Aminoquinol Agonist / Unkown
HY-123439 FTY720-C2 Inhibitor 99.64% Unkown
HY-D3420 Neuro-DiI / Unkown
HY-RS05361 GDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119910B Aminoquinol phosphate Agonist / Unkown
HY-119910C Aminoquinol triphosphate Agonist / Unkown
HY-RS16523 Gdnf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22954 Gdnf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W101298S (Leu-13C6,15N)-Ile-OH TFA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdnf NCBI NCBI:2668