GFRα2/3-IN-1
GFRα2/3-IN-1 (Compound 16) is a selective GFRα2/3 inhibitor with IC50 values of 0.1 and 0.2 μM for GFRα2 and GFRα3, respectively. GFRα2 is a glial cell line-derived neurotrophic factor (GDNF) receptor related to GFRα1, GFRα2/3-IN-1 can be used for pain and itch research.
For research use only. We do not sell to patients.
- Formula: C36H39N5O3
- Molecular Weight:589.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 589.73
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Formula C36H39N5O3
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SMILES
CNC([C@@H](C1CCCCC1)NC(CC2=CC(O[C@@H]3CC4=C(C3)C=C(C=C4)C5=CN=C(N=C5)NC6=CC=CC=C6)=CC=C2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jing S, et al. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 1997 Dec 26;272(52):33111-7. [Content Brief]
[2]. Johnson SL, et al. Discovery of the first selective, small-molecule GFRα2/3 inhibitors through DNA-encoded library technology. Bioorg Med Chem Lett. 2024 Sep 15;110:129889. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GFRα2/3-IN-1 Related Classifications
HY-163840 Related Classifications
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