Hrh2 - histamine receptor H 2 Gene

Also Known as H2R; HH2R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25461

About Hrh2

Primary_assembly 17: 10,368,298-10,407,631 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 249 orthologues, 35 paralogues and is associated with 11 phenotypes. Biased expression in Brain (RPKM 17.7), Spleen (RPKM 8.2) and 7 other tissues.

Summary

Enables heterocyclic compound binding activity and Histamine Receptor activity. Involved in cellular response to histamine and negative regulation of arachidonic acid secretion. Located in membrane. Biomarker of transient cerebral ischemia. Orthologous to human HRH2 (Histamine Receptor H2). [provided by Alliance of Genome Resources, Apr 2022]

Hrh2 Products (1)

mRNA Protein Name
NM_001413011.1 NP_001399940.1 histamine H2 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
1313563 RGD
enables histamine receptor activity IDA
IDA: Inferred from direct assay
1313563 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to histamine IEP
IEP: Inferred from expression pattern
1313563 RGD
involved in negative regulation of arachidonate secretion IDA
IDA: Inferred from direct assay
1313563 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh2 Protein Structure

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (18 - 297)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (19 - 45)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (52 - 79)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (90 - 120)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (132 - 152)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (177 - 207)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (225 - 255)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (265 - 290)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
Protein Preferred Names Protein Names

histamine H2 receptor

  • gastric receptor I

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-170442 ECI830 Inhibitor 98.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156959 Ovalicin Inhibitor / Unkown
HY-RS06362 HRH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06363 Hrh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06364 Hrh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20393 Dhx15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hrh2 NCBI NCBI:3274