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NAALADL2 - N-acetylated alpha-linked acidic dipeptidase like 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 254827

About NAALADL2

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:174,440,982-175,810,548 (from NCBI)

This gene has 12 transcripts (splice variants), 184 orthologues and 5 paralogues. Ubiquitous expression in prostate (RPKM 1.4), gall bladder (RPKM 1.0) and 24 other tissues.

Summary

Predicted to enable metalloexopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within response to bacterium. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NAALADL2 Products (1)

mRNA	Protein	Name
NM_207015.3	NP_996898.2	inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAALADL2 Protein Structure

Peptidase_M28

0
200
400
600
795 a.a.

Protein Preferred Names	Protein Names
inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2	N-acetylated alpha-linked acidic dipeptidase 2

NAALADL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAALADL2	Q58DX5	GPR25	Homo sapiens	O00155	Y2H Prey Pooling	25416956
Intra	NAALADL2	Q58DX5	GPR25	Homo sapiens	O00155	Y2H Array	25416956
Intra	NAALADL2	Q58DX5	GRM2	Homo sapiens	Q14416	Validated Y2H	25416956
Intra	NAALADL2	Q58DX5	GRM2	Homo sapiens	Q14416	Y2H Array	25416956
Intra	NAALADL2	Q58DX5	SLC30A3	Homo sapiens	Q99726	Validated Y2H	25416956
Intra	NAALADL2	Q58DX5	SLC30A3	Homo sapiens	Q99726	Y2H Array	25416956
Intra	NAALADL2	Q58DX5	ITM2B	Homo sapiens	Q9Y287	Validated Y2H	25416956
Intra	NAALADL2	Q58DX5	LAPTM4B	Homo sapiens	Q86VI4	Validated Y2H	25416956
Intra	NAALADL2	Q58DX5	LAPTM4B	Homo sapiens	Q86VI4	Y2H Array	25416956
Intra	NAALADL2	Q58DX5	LAPTM4B	Homo sapiens	Q86VI4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NAALADL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71559	NAALADL2 Protein, Human (His-SUMO)	Q58DX5-1 (G143-N795)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Chromosome 6pter-P24 Deletion Syndrome	6p Subtelomeric Deletion Syndrome 6p25 Microdeletion Syndrome Distal Monosomy 6p Distal Deletion 6p Monosomy 6p25
Facial Clefting, Oblique, 1	Oculomaxillofacial Dysostosis Oculomaxillofacial Dysplasia With Oblique Facial Clefts OBLFC1 Oblique Facial Clefting 1 Tessier Number 4 Facial Cleft Oblique Facial Cleft Orbitofacial Cleft Oblique Facial Clefts Richieri Costa Gorlin Syndrome Richieri-Costa-Gorlin Syndrome Facial Clefting, Oblique, Type 1
Teebi Hypertelorism Syndrome 1	Teebi Hypertelorism Syndrome Brachycephalofrontonasal Dysplasia Hypertelorism, Teebi Type TBHS1 Tbhs Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype Opitz Gbbb Syndrome Type Ii Specc1l-Related Hypertelorism Syndrome Opitz Gbbb Syndrome, Type Ii, Formerly Gbbb2, Formerly Opitz Bbbg Syndrome, Type Ii, Formerly Bbbg2, Formerly Opitz-G Syndrome, Type Ii, Formerly Ogs2, Formerly Opitz Bbb Syndrome, Type Ii, Formerly Hypertelorism-Hypospadias Syndrome, Formerly Hypertelorism With Esophageal Abnormality And Hypospadias, Formerly Opitz Oculogenitolaryngeal Syndrome, Type Ii, Formerly Opitz-Frias Syndrome, Formerly Teebi Hypertelorism Syndrome-1 Craniofrontonasal Dysplasia, Teebi Type Bbb Syndrome Gbbb Syndrome G Syndrome Hypertelorism-Hypospadias Syndrome Hypertelorism With Esophageal Abnormality And Hypospadias Hypospadias-Dysphagia Syndrome Ogs2 Opitz Bbbg Syndrome Opitz-Frias Syndrome Opitz Gbbb Syndrome, Autosomal Dominant Opitz-G Syndrome, Type Ii Opitz Oculogenitolaryngeal Syndrome, Type Ii Opitz Gbbb Syndrome, Type Ii Teebi Syndrome Opitz-G Syndrome, Type 2 Opitz Gbbb Syndrome, X-Linked Digeorge Syndrome
Heart Aneurysm	Cardiac Aneurysm
Chromosome 1p36 Deletion Syndrome	1p36 Deletion Syndrome Deletion 1p36 Monosomy 1p36 Subtelomeric 1p36 Deletion Monosomy 1p36 Syndrome Distal Monosomy 1p36 Del(1)(P36) Deletion 1pter Monosomy 1pter
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08995	NAALADL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20667	Naaladl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27178	Naaladl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAALADL2	VGNC	VGNC:43599
Felis catus	NAALADL2	VGNC	VGNC:102784
Bos taurus	NAALADL2	VGNC	VGNC:106832
Rattus norvegicus	NAALADL2	RGD	RGD:1565147
Mus musculus	NAALADL2	MGD	MGI:2685867
Macaca mulatta	NAALADL2	VGNC	VGNC:83927
Others	NAALADL2	NCBI