Oxt - oxytocin/neurophysin I prepropeptide Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25504

Summary

Enables neuropeptide hormone activity and Oxytocin Receptor binding activity. Involved in several processes, including mating; positive regulation of smooth muscle contraction; and regulation of secretion. Located in extracellular space; secretory granule; and terminal bouton. Used to study gastric ulcer and hypertension. Biomarker of hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

Oxt Products (1)

mRNA Protein Name
NM_012996.3 NP_037128.1 oxytocin-neurophysin 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide hormone activity IDA
IDA: Inferred from direct assay
19560475 RGD
enables oxytocin receptor binding IDA
IDA: Inferred from direct assay
15821089 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15927785 RGD
Biological Process GO Annotation Evidence References Source
involved in drinking behavior IDA
IDA: Inferred from direct assay
15380376 RGD
involved in eating behavior IDA
IDA: Inferred from direct assay
15380376 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18936075 RGD
involved in grooming behavior IDA
IDA: Inferred from direct assay
17505467 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
15316117 RGD
involved in male mating behavior IEP
IEP: Inferred from expression pattern
18655888 RGD
involved in maternal aggressive behavior IEP
IEP: Inferred from expression pattern
18655888 RGD
involved in maternal behavior IDA
IDA: Inferred from direct assay
18513132 RGD
involved in memory IEP
IEP: Inferred from expression pattern
18304743 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
18562099 RGD
involved in negative regulation of urine volume IDA
IDA: Inferred from direct assay
18057218 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
19120122 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
10497238 RGD
involved in positive regulation of female receptivity IDA
IDA: Inferred from direct assay
11264328 RGD
involved in positive regulation of hindgut contraction IDA
IDA: Inferred from direct assay
19258489 RGD
involved in positive regulation of norepinephrine secretion IDA
IDA: Inferred from direct assay
14656297 RGD
involved in positive regulation of ossification IDA
IDA: Inferred from direct assay
18257653 RGD
involved in positive regulation of penile erection IDA
IDA: Inferred from direct assay
18671741 RGD
involved in positive regulation of prostaglandin secretion IDA
IDA: Inferred from direct assay
9575824 RGD
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
16488155 RGD
involved in positive regulation of synaptic transmission IDA
IDA: Inferred from direct assay
17314286 RGD
involved in positive regulation of uterine smooth muscle contraction IDA
IDA: Inferred from direct assay
19164477 RGD
involved in regulation of heart rate IDA
IDA: Inferred from direct assay
3668162 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
16157794 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
17383105 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
11168841 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
18609307 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
18823708 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19258489 RGD
involved in response to ether IEP
IEP: Inferred from expression pattern
1943445 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
18832082 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17553493 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
19248249 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12504828 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
19246538 RGD
involved in response to progesterone IDA
IDA: Inferred from direct assay
17280592 RGD
involved in response to prostaglandin E IEP
IEP: Inferred from expression pattern
19017254 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
15316117 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
12588901 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
19022308 RGD
involved in social behavior IDA
IDA: Inferred from direct assay
17540347 RGD
involved in sperm ejaculation IDA
IDA: Inferred from direct assay
18552879 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18953097 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
3883189 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
11456414 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
18987209 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oxytocin-neurophysin 1

  • OT-NPI

  • oxcytocin

  • oxytocin, prepropeptide

  • oxytocin/neurophysin (Oxt) gene, complete gene, complete cds

  • oxytocin/neurophysin 1 prepropeptide

Oxt Antibodies

Cat. No. Product Name Application Reactivity
HY-P87000 Oxytocin-neurophysin 1/OXT Antibody (YA6693) IHC-F, IF-Tissue Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4990 Pro8-Oxytocin Activator 99.68% Unkown
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% Unkown
HY-RS09893 OXT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18742 Oxt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25229 Oxt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oxt NCBI NCBI:5020