OXT - oxytocin/neurophysin I prepropeptide Gene

Also Known as OT; OT-NPI; OXT-NPI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5020

About OXT

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,071,620-3,072,517 (from NCBI)

This gene has 1 transcript (splice variant), 302 orthologues and 1 paralogue. Biased expression in liver (RPKM 1.6), kidney (RPKM 0.7) and 5 other tissues.

Summary

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

OXT Products (1)

mRNA	Protein	Name
NM_000915.4	NP_000906.1	oxytocin-neurophysin 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OXT Protein Structure

Hormone_4

Hormone_5

0
100
125 a.a.

Protein Preferred Names	Protein Names
oxytocin-neurophysin 1	neurophysin I

OXT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OXT	P01178	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	OXT	P01178	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	OXT	P01178	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OXT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71766	OXT Protein, Human (P.pastoris, His)	P01178 (A32-R125)	≥ 90%, as determined by reducing SDS-PAGE.

OXT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810307	Oxytocin Antibody	IHC-P, IHC-F, ICC/IF, ELISA, IF-Tissue	Human
HY-P810307A	Oxytocin Antibody (PBS Only)	IHC-P, IHC-F, ICC/IF, ELISA, IF-Tissue	Human
HY-P87001	Oxytocin-neurophysin 1/OXT Antibody (YA6694)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Endometritis
Chorioamnionitis
Placenta Accreta
Asphyxia Neonatorum	Birth Asphyxia Postnatal Asphyxia Asphyxia - Birth Asphyxia, In Liveborn Infant Hypoxia Neonatorum Hypoxia, In Liveborn Infant Intrapartum Asphyxia Neonatal Asphyxia Newborn Asphyxia Asphyxia In Liveborn Infant Asphyxia Of Newborn Nos Perinatal Asphyxia Perinatal Hypoxia Newborn Asphyxiation
Uterine Inversion	Inversion Of Uterus During Delivery
Alexithymia
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Meconium Aspiration Syndrome	Neonatal Aspiration Of Meconium Meconium Aspiration Mas Meconium Aspiration Syndrome Of Newborn Meconium Inhalation Mas - [Meconium Aspiration Syndrome] Meconium Aspiration Nos Meconium Aspiration Syndrome Nos Meconium Pneumonitis Meconium Stained Liqueur Aspiration
Pain Agnosia	Analgesia
Morphine Dependence
Placenta Praevia	Placenta Previa Haemorrhage From Placenta Previa Placenta Previa Haemorrhage Lateral Placenta Low Implantation Of Placenta Nos Or With Haemorrhage Total Placenta Previa Total Placenta Praevia Nos Or With Haemorrhage Placental Previa Haemorrhage Pp - [Placenta Previa] Placenta Previa Marginalis Placenta Previa Partialis Partial Placenta Previa Placenta Previa Centralis Low Implantation Of Placenta Low Implantation Or Insertion Of Placenta Low Insertion Of Placenta Low Lying Placenta Marginal Placenta Marginal Placenta Praevia Nos Or With Haemorrhage Marginal Placenta Previa Marginal Placental Haemorrhage Partial Placenta Praevia Nos Or With Haemorrhage
Diabetes Insipidus
Inhibited Male Orgasm	Male Orgasmic Disorder Psychosexual Dysfunction With Male Orgasmic Disorder
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Neonatal Jaundice	Neonatal Hyperbilirubinemia Neonatal Icterus Jaundice Neonatal Jaundice, Neonatal Hyperbilirubinemia, Neonatal
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Conduct Disorder
Myoma	Muscle Benign Neoplasm Myomatous Neoplasm Neoplasms, Muscle Tissue Benign Neoplasm Of The Muscle Muscle Neoplasm Muscle Tissue Neoplasm Myomatous Tumor Neoplasm Of Muscle Muscle Neoplasms Myomas
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Postpartum Depression	Maternity Blues Postnatal Depression Depression, Postpartum Post-Partum Depression Depression Postpartum
Vaginal Discharge
Dissociative Disorder	Dissociative Disorders Dissociative Disease Dissociative Reaction
Psychosexual Disorder	Psychosexual Disorders
Cervical Incompetence	Uterine Cervical Incompetence
Central Diabetes Insipidus	Neurogenic Diabetes Insipidus Diabetes Insipidus Cranial Type Diabetes Insipidus Neurogenic Diabetes Insipidus Neurohypophyseal Neurohypophyseal Diabetes Insipidus Pituitary Diabetes Insipidus Cdi Doid:0081055 Diabetes Insipidus Di - [Diabetes Insipidus] Adh - [Antidiuretic Hormone Secretion] Deficiency Diabetes Mellitus Insipidus Familial Diabetes Insipidus Antidiuretic Hormone Hyposecretion Vasopressin Deficiency Syndrome Primary Central Diabetes Insipidus Vasopressin Deficiency Vasopressin Hyposecretion Diabetes Insipidus Secondary To Vasopressin Deficiency
Sexual Sadism	Sadism
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Sexual Health Disorder	Sexual Health
Fetal Macrosomia
Lactocele	Galactocele Galactocoele Lacteal Cyst
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Oligohydramnios	Oligohydramnios - Delivered Antepartum Oligohydramnios Delivered Oligohydramnios Oligohydramnios, Antepartum Condition Or Complication Deficient Liquor Oligohydramnios, Unspecified Trimester Reduced Liquor Volume
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Eclampsia	Eclampsia In Puerperium Postpartum Eclampsia Eclampsia, Postpartum Puerperal Eclampsia
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Transvestism	Dual-Role Transvestism Fetishistic Transvestism Cross Dresser Transvestic Fetishism
Separation Anxiety Disorder	Separation Anxiety Disorder Of Childhood
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Endometrial Disease	Endometrial Disorder Endometrial Diseases
Hypoactive Sexual Desire Disorder	Lack Or Loss Of Sexual Desire Sexual Dysfunctions, Psychological
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Animal Phobia	Zoophobia Fear Of Animals
Breast Abscess	Abscess Of Breast
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Diabetes Insipidus, Neurohypophyseal	Neurohypophyseal Diabetes Insipidus Cdi Pituitary Diabetes Insipidus Vasopressin Defective Diabetes Insipidus Vasopressin Deficiency Central Diabetes Insipidus Diabetes Insipidus, Neurogenic Diabetes Insipidus, Primary Central Diabetes Insipidus, Cranial Type Diabetes Insipidus Secondary To Vasopressin Deficiency Diabetes Insipidus, Central Diabetes Insipidus, Pituitary NDI Diabetes Insipidus Cranial Type Neurogenic Diabetes Insipidus Primary Central Diabetes Insipidus
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Pedophilia	Paedophilia
Kluver-Bucy Syndrome	Bilateral Temporal Lobe Disorder Klüver-Bucy Syndrome Klver-Bucy Syndrome Kluver Bucy Syndrome Memory Loss, Extreme Sexual Behavior, Placidity, And Visual Distractibility Post-Encephalitic Kluver Bucy Syndrome Post-Traumatic Kluver Bucy Syndrome
Specific Developmental Disorder
Paraphilia Disorder	Paraphilia Paraphilias
Fetishism	Fetishism, Psychiatric
Amenorrhea	Absence Of Menstruation Amenia
Placental Abruption	Abruptio Placentae Abruptio Placenta Abortion, Threatened Threatened Miscarriage Haemorrhage Specified As Due To Threatened Abortion Spontaneous Threatened Abortion
Pulmonary Edema
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Postmenopausal Atrophic Vaginitis	Atrophic Vaginitis Senile Vaginitis Senile Atrophic Vaginitis Atrophy Of Vagina Vaginal Atrophy
Phobia, Specific	Specific Phobia Simple Phobia Phobia, Simple Isolated Phobia
Subserous Uterine Fibroid	Subserous Leiomyoma Of Uterus
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Serotonin Syndrome	Serotonergic Syndrome Serotonin Storm Serotonin Toxicity Serotonin Toxidrome Malignant Carcinoid Syndrome
Parametritis	Pelvic Cellulitis
Narcissistic Personality Disorder
Spontaneous Tension Pneumothorax	Tension Pneumothorax
Inappropriate Adh Syndrome	Syndrome Of Inappropriate Antidiuretic Hormone Secretion Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone Siadh Syndrome Of Inappropriate Vasopressin Secretion Syndrome Of Inappropriate Secretion Of Adh Inappropriate Secretion Of Antidiuretic Hormone Syndrome Of Inappropriate Antidiuresis Siadh - [Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone] Antidiuretic Hormone Syndrome Hormone Secretion Inadequate Antidiuretic Hormone Secretion Syndrome Schwartz-Bartter Syndrome Siad - [Syndrome Of Inappropriate Antidiuresis] Hypersecretion Of Antidiuretic Hormone
Mental Depression	Depression Depressive Disorder
Sexual Masochism	Masochism
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Epilepsy, Idiopathic Generalized 13	Epilepsy, Childhood Absence 4 EIG13 Epilepsy, Idiopathic Generalized, Susceptibility To, 13 Epilepsy, Childhood Absence, Susceptibility To, 4 Idiopathic Generalized Epilepsy 13 Epilepsy, Juvenile Myoclonic, Susceptibility To, 5 Epilepsy, Juvenile Myoclonic 5 ECA4 Juvenile Myoclonic Epilepsy 5 EJM5 Susceptibility To Juvenile Myoclonic Epilepsy 5 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 13
Prosopagnosia
Multiple Personality Disorder	Dissociative Identity Disorder Multiple Personality
Hemometra	Hematometra
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Premature Ejaculation
Thiopental Allergy	Penthiobarbital Allergy Pentothiobarbital Allergy
Disease Of Mental Health	Mental Health Mental Disorders
Placenta Disease	Placenta Diseases Placenta Disorder Pregnancy Complications Placenta Disorders
Voyeurism
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Funisitis
Lipoid Proteinosis Of Urbach And Wiethe	Lipoid Proteinosis Urbach-Wiethe Disease Hyalinosis Cutis Et Mucosae Lipid Proteinosis Lipoproteinosis Urbach Wiethe Disease Lipoglycoproteinosis Lipoidosis Cutis Et Mucosae Lipoidproteinosis Urbach-Wiethe Lipoid Proteinosis Urbach-Wiethe Syndrome LIP Proteinosis Lipoid
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Polyhydramnios
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Somatization Disorder	Somatoform Disorders Briquet'S Disorder Polysomatising Disorder Somatisation Disorder Somatoform Disorder
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Intermittent Explosive Disorder	Explosive Personality Disorder
Flying Phobia	Aerophobia
Aspiration Pneumonitis	Chemical Pneumonitis Mendelson'S Syndrome Aspiration Pneumonia Pneumonitis Due To Fumes And/Or Vapors Toxic Pneumonitis Mendelson'S Syndrome Resulting From A Procedure Mendelson Syndrome Resulting From A Procedure Pulmonary Acid Aspiration Syndrome Pneumonitis Due To Inhalation Of Gastric Secretions Mendelson Syndrome Due To Anaesthesia During Labour And Delivery Inhalation Of Stomach Contents Or Secretions, Nos Due To Anaesthesia During Labour And Delivery
Persistent Fetal Circulation Syndrome	Persistent Fetal Circulation Fetal Circulation Persistent Pulmonary Hypertension Of The Newborn Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins Persistent Foetal Circulation Persistent Foetal Circulation Syndrome Pfc - [Persistent Fetal Circulation] Syndrome Pphn - [Persistent Pulmonary Hypertension Of The Newborn] Newborn Pulmonary Hypertension Primary Pulmonary Hypertension Of Newborn
Uterine Benign Neoplasm
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Adjustment Disorder	Adjustment Reaction Adjustment Disorders Adjustment Disease Brief Situational Non-Psychotic Disorder Adaptation Reaction Nos Emotional Crisis Situational Disorder Situational Disturbance Situational Maladjustment Situational Reaction Situational Reaction With Maladjustment Transient Situational Disturbance
Nephrogenic Syndrome Of Inappropriate Antidiuresis	NSIAD
Severe Pre-Eclampsia	Severe Preeclampsia Antepartum Severe Pre-Eclampsia Postpartum Severe Pre-Eclampsia Severe Pre-Eclampsia, With Delivery Severe Toxemia Severe Pre-Eclampsia, Antepartum Condition Or Complication Severe Pre-Eclampsia, Postpartum Condition Or Complication Severe Puerperal Pre-Eclampsia Severe Pre-Eclamptic Toxaemia Severe Pet - [Pre-Eclamptic Toxaemia]
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Generalized Anxiety Disorder	Anxiety Generalized
Neurotic Disorder	Neurosis Reactive Depression Adjustment Disorders Neurotic Disorders Depressive Neurosis Neurotic Depression Neurotic Depression Reactive Type Neurotic Depressive State Psychoneurosis Depressive Disorder Depression, Neurotic
Reproductive Organ Benign Neoplasm
Cortisone Reductase Deficiency 2	CORTRD2
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Vaginal Adenoma
Tetanus Neonatorum	Neonatal Tetanus NNT Trismus Neonatorum Newborn Trismus
Supine Hypotensive Syndrome	Maternal Hypotension Syndrome Antepartum Maternal Hypotension Syndrome Postpartum Maternal Hypotension Syndrome Maternal Hypotension Syndrome, Antepartum Condition Or Complication Maternal Hypotension Syndrome, Postpartum Condition Or Complication Maternal Hypotension Syndrome, Unspecified Trimester
Schaaf-Yang Syndrome	Prader-Willi-Like Syndrome Chitayat-Hall Syndrome SHFYNG Pwls Magel2-Related Prader-Willi-Like Syndrome Magel2-Related Pwls Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies Pws Due To A Point Mutation Pws Due To Point Mutation Prader-Willi Syndrome Due To A Point Mutation Prader-Willi Syndrome Due To Point Mutation Pws-Like
Neonatal Abstinence Syndrome	Drug Withdrawal Syndrome In Newborn
Atypical Autism	Pdd
Dysthymic Disorder	Dysthymia Chronic Depressive Disorder Chronic Depression Depressive Personality Depressive Personality Disorder Persistent Depressive Disorder Persistent Depression
Pigmentation Disease	Pigmentation Disorders Skin Pigmentation Disorder
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Mild Pre-Eclampsia	Mild Toxemia
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Acquired Hemangioma
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Vaginal Benign Neoplasm
Ectopic Pregnancy	Eccyesis Pregnancy Ectopic Pregnancy, Ectopic Ectopic Pregnancies Extrauterine Gestation Or Pregnancy Extrauterine Pregnancy Ep - [Ectopic Pregnancy] Ectopic Mole Aborted Ectopic Pregnancy Ruptured Ectopic Pregnancy
Melancholia
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Mood Disorder	Mood Disorders Episodic Mood Disorder
Anaerobic Meningitis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Haverhill Fever	Streptobacillosis Streptobacillary Rat-Bite Fever Streptobacillary Fever Rat-Bite Fever Due To Streptobacillus Moniliformis Erythema Arthriticum Epidemicum Epidemic Arthritic Erythema
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Breast Juvenile Papillomatosis	Juvenile Papillomatosis Of The Breast
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Diabetes Mellitus	Diabetes
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4990	Pro8-Oxytocin	Activator	99.68%	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	99.68%	Unkown
HY-RS09893	OXT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18742	Oxt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25229	Oxt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OXT	MGD	MGI:97453
Macaca mulatta	OXT	VGNC	VGNC:75730
Bos taurus	OXT	VGNC	VGNC:32515
Canis familiaris	OXT	VGNC	VGNC:54339
Felis catus	OXT	VGNC	VGNC:108054
Rattus norvegicus	OXT	RGD	RGD:3238
Others	OXT	NCBI