Ccl3 - C-C motif chemokine ligand 3 Gene

Also Known as Scya3; MIP-1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25542

Summary

Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and positive regulation of osteoclast differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including Chagas disease; anterior uveitis; nephritis (multiple); renal fibrosis; and status epilepticus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccl3 Products (1)

mRNA Protein Name
NM_013025.2 NP_037157.2 C-C motif chemokine 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables chemokine activity IDA
IDA: Inferred from direct assay
10466578 RGD
Biological Process GO Annotation Evidence Références Source
involved in leukocyte chemotaxis IDA
IDA: Inferred from direct assay
7722328 RGD
involved in neutrophil chemotaxis IDA
IDA: Inferred from direct assay
7722328 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
10466578 RGD
involved in positive regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
9920817 RGD
involved in regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
19497618 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17666800 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 3

  • MIP-1-alpha

  • Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)

  • chemokine (C-C motif) ligand 3

  • macrophage inflammatory protein 1-alpha

  • small-inducible cytokine A3

Recombinant Ccl3 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71898 MIP-1 alpha/CCL3 Protein, Rat P50229 (A24-A92) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-152846 Flizasertib Inhibitor 99.9% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-149202 UT-11 Inhibitor 98.25% Unkown
HY-RS02099 CCL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-RS02100 CCL3L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120406 PLS-123 / Unkown
HY-124668 CCR1 antagonist 12 Antagonist / Unkown
HY-RS02101 CCL3L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W505771 Seselin Inhibitor 99.55% Unkown
HY-174753 Human CCL3L1 mRNA / Unkown
HY-RS16642 Ccl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23076 Ccl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl3 NCBI NCBI:6348