CCL3 - C-C motif chemokine ligand 3 Gene
Also Known as MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
Species: Homo sapiens
About CCL3
This gene has 3 transcripts (splice variants), 1 gene allele, 185 orthologues, 25 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 81.4), liver (RPKM 17.1) and 10 other tissues.
Summary
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to Infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
CCL3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002983.3 | NP_002974.1 | C-C motif chemokine 3 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables CCR1 chemokine receptor binding |
IPI
IPI: Inferred from physical interaction
|
7545673 | GOA |
| enables CCR5 chemokine receptor binding |
IPI
IPI: Inferred from physical interaction
|
8699119 | GOA |
| enables chemoattractant activity |
IDA
IDA: Inferred from direct assay
|
10072545 | GOA |
| enables chemokine activity |
IDA
IDA: Inferred from direct assay
|
10072545 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
20959807 | GOA |
| enables kinase activity |
IDA
IDA: Inferred from direct assay
|
21403648 | GOA |
| enables phospholipase activator activity |
IDA
IDA: Inferred from direct assay
|
10734056 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20959807 | GOA |
| enables protein kinase activity |
IDA
IDA: Inferred from direct assay
|
10734056 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
21784977 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
19523456 | GOA |
| located in extracellular region |
IDA
IDA: Inferred from direct assay
|
20041150 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
20167378 | GOA |
CCL3 Protein Structure
IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (27 - 86)
- 0
- 92 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
C-C motif chemokine 3 |
|
CCL3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCL3 | P10147 | IDE | Homo sapiens | P14735 | 20959807 | |
|
Intra
|
CCL3 | P10147 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
CCL3 | P10147 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
CCL3 | P10147 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
CCL3 | P10147 | ARHGAP32 | Homo sapiens | A7KAX9 | 33961781 | |
|
Intra
|
CCL3 | P10147 | ADAMTS2 | Homo sapiens | O95450 | 33961781 | |
|
Intra
|
CCL3 | P10147 | ANGEL2 | Homo sapiens | Q5VTE6 | 33961781 | |
|
Intra
|
CCL3 | P10147 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
CCL3 | P10147 | ADAMTS17 | Homo sapiens | Q8TE56 | 33961781 | |
|
Intra
|
CCL3 | P10147 | AMZ2 | Homo sapiens | Q86W34 | 33961781 | |
|
Intra
|
CCL3 | P10147 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
CCL3 | P10147 | CCL3 | Homo sapiens | P10147 | 20959807 | |
|
Intra
|
CCL3 | P10147 | CCL3 | Homo sapiens | P10147 | 20959807 | |
|
Intra
|
CCL3 | P10147 | AGRN | Homo sapiens | O00468 | 33961781 | |
|
Intra
|
CCL3 | P10147 | ADAMTS1 | Homo sapiens | Q9UHI8 | 33961781 | |
|
Intra
|
CCL3 | P10147 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
CCL3 | P10147 | B3GLCT | Homo sapiens | Q6Y288 | 33961781 | |
|
Intra
|
CCL3 | P10147 | CCL3 | Homo sapiens | P10147 | 20959807 | |
|
Intra
|
CCL3 | P10147 | ARSB | Homo sapiens | P15848 | 33961781 | |
|
Intra
|
CCL3 | P10147 | ADAMTS15 | Homo sapiens | Q8TE58 | 33961781 | |
|
Intra
|
CCL3 | P10147 | ABHD15 | Homo sapiens | Q6UXT9 | 33961781 |
Recombinant CCL3 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7256 | MIP-1 alpha/CCL3 Protein, Human | P10147 (S24-A92) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7256AF | Animal-Free MIP-1 alpha/CCL3 Protein, Human (His) | P10147 (A27-A92) | ≥ 95%, as determined by reducing SDS-PAGE. |
CCL3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P86801 | CCL3/MIP-1 alpha Antibody (YA6494) | WB, ICC/IF, IHC-P | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Human Immunodeficiency Virus Type 1 |
|
|
| Aseptic Meningitis |
|
|
| Loiasis |
|
|
| Tropical Spastic Paraparesis |
|
|
| Bronchiolitis |
|
|
| Pulmonary Eosinophilia |
|
|
| Extrinsic Allergic Alveolitis |
|
|
| Mast-Cell Leukemia |
|
|
| Chromoblastomycosis |
|
|
| Chronic Eosinophilic Pneumonia |
|
|
| Covid-19 |
|
|
| Whiplash |
|
|
| Pneumonia |
|
|
| Aspergillosis |
|
|
| Radiculopathy |
|
|
| Bone Disease |
|
|
| Mesangial Proliferative Glomerulonephritis |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Pulmonary Sarcoidosis |
|
|
| Pulmonary Tuberculosis |
|
|
| Pulmonary Fibrosis |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Pleural Tuberculosis |
|
|
| Multicentric Carpotarsal Osteolysis Syndrome |
|
|
| Demyelinating Disease |
|
|
| Meningitis |
|
|
| Prostatitis |
|
|
| Palladium Allergic Contact Dermatitis |
|
|
| Toxoplasmosis |
|
|
| Respiratory Syncytial Virus Infectious Disease |
|
|
| Viral Infectious Disease |
|
|
| Encephalitis |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Schistosomiasis |
|
|
| Immune Deficiency Disease |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Sarcoidosis 1 |
|
|
| Malaria |
|
|
| Aggressive Periodontitis |
|
|
| Periapical Granuloma |
|
|
| Neuritis |
|
|
| Ileus |
|
|
| Dengue Disease |
|
|
| Type 1 Diabetes Mellitus 22 |
|
|
| Interstitial Lung Disease 2 |
|
|
| Chagas Disease |
|
|
| Rheumatoid Arthritis |
|
|
| Multiple Sclerosis |
|
|
| Myocarditis |
|
|
| Disease By Infectious Agent |
|
|
| Plasmacytoma |
|
|
| Severe Covid-19 |
|
|
| Critical Covid-19 |
|
|
| Interstitial Lung Disease |
|
|
| Coronavirus Infectious Disease |
|
|
| Aplastic Anemia |
|
|
| Viral Pneumonia |
|
|
| Asthma |
|
|
| Allergic Disease |
|
|
| Lyme Disease |
|
|
| Complement Component 6 Deficiency |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Middle East Respiratory Syndrome |
|
|
| Autoimmune Disease |
|
|
| Myeloma, Multiple |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Bacterial Infectious Disease |
|
|
| Middle Ear Squamous Cell Carcinoma |
|
|
| Systemic Lupus Erythematosus |
|
|
| Myocardial Infarction |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
|
| Bronchopneumonia |
|
|
| Marburg Hemorrhagic Fever |
|
|
| Bacterial Pneumonia |
|
|
| Behcet Syndrome |
|
|
| Ebola Hemorrhagic Fever |
|
|
| Avian Influenza |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Inflammatory Bowel Disease |
|
|
| Leukocyte Disease |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Respiratory Failure |
|
|
| Bronchial Disease |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Cystic Fibrosis |
|
|
| Stroke, Ischemic |
|
|
| Diabetes Mellitus |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Hypertension, Essential |
|
|
| Skin Disease |
|
|
| Connective Tissue Disease |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CCL3 | MGD | MGI:98260 |
| Rattus norvegicus | CCL3 | RGD | RGD:3647 |