Sstr4 - somatostatin receptor 4 Gene

Also Known as Smstr4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25555

About Sstr4

Primary_assembly 3: 135,854,826-135,856,689 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 100 orthologues, 14 paralogues and is associated with 3 phenotypes.

Summary

Enables Somatostatin Receptor activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of arachidonic acid secretion; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Biomarker of status epilepticus. Orthologous to human SSTR4 (Somatostatin Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Sstr4 Products (1)

mRNA Protein Name
NM_013036.3 NP_037168.1 somatostatin receptor type 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17950729 RGD
enables somatostatin receptor activity IDA
IDA: Inferred from direct assay
1362243 RGD
Biological Process GO Annotation Evidence References Source
involved in cell migration IDA
IDA: Inferred from direct assay
17945410 RGD
involved in cell migration IMP
IMP: Inferred from mutant phenotype
16534498 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
14512709 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
10805921 RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8175684 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
8175684 RGD
involved in positive regulation of arachidonate secretion IDA
IDA: Inferred from direct assay
8175684 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr4 Protein Structure

7tmA_SSTR4

7tmA_SSTR4: cd15973 (43 - 317)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (44 - 70)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (77 - 103)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (114 - 144)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (156 - 178)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (203 - 232)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (247 - 277)

7tmA_SSTR4

7tmA_SSTR4: cd15973 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 4

  • SS-4-R

  • SS4-R

  • SS4R

  • Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-105172 TT-232 Agonist 98.72% Phase 2
HY-P0024 Veldoreotide Activator / Phase 2
HY-P1384 L803 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-139347 Mazisotine Agonist 99.54% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.97% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-W1117589 SSTR4 agonist 6 Agonist / Unkown
HY-142701 SSTR4 agonist 4 Activator / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-172147 SSTR4 agonist 5 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr4 NCBI NCBI:6754