SSTR4 - somatostatin receptor 4 Gene

Also Known as SS4R; SST4; SS4-R; SS-4-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6754

About SSTR4

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,035,312-23,039,237 (from NCBI)

This gene has 1 transcript (splice variant), 100 orthologues and 17 paralogues.

Summary

Somatostatin acts at many sites to inhibit the release of many Hormones and Other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]

SSTR4 Products (1)

mRNA Protein Name
NM_001052.4 NP_001043.2 somatostatin receptor type 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19426801 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSTR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (64 - 311)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 4

  • G-protein coupled receptor

SSTR4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SSTR4 P31391 SSTR5 Homo sapiens P35346
Anti Tag CoIP
19426801
Intra
SSTR4 P31391 SSTR5 Homo sapiens P35346
IF
19426801
Intra
SSTR4 P31391 SSTR5 Homo sapiens P35346
FRET
19426801
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hormone Producing Pituitary Cancer

  • Growth Hormone Producing Pituitary Tumor

  • Pituitary Tumors, Hormone Producing

  • Somatotropinoma

  • Growth Hormone-Producing Pituitary Gland Neoplasm
Prolactinoma

  • Prolactin-Producing Pituitary Gland Adenoma

  • Prolactin-Secreting Pituitary Adenoma

  • Forbes-Albright Syndrome

  • Lactotroph Adenoma

  • Prl-Secreting Pituitary Adenoma

  • Prloma

  • Pituitary Lactotrophic Adenoma

  • Familial Prolactinoma

  • Pituitary Adenoma, Prolactin-Secreting

  • Prolactinoma Of Pituitary Gland

  • PSPA
Hyperpituitarism
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Protection Against

  • Lung Cancer, Susceptibility To

  • Adenocarcinoma Of Lung, Somatic

  • Nonsmall Cell Lung Cancer

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Functioning Pituitary Adenoma

  • Secretory Adenoma Of The Pituitary Gland

  • Endocrine Active Pituitary Adenoma

  • Secreting Pituitary Adenoma

  • Pituitary Adenoma, Functioning
Sotos Syndrome

  • Cerebral Gigantism

  • SOTOS

  • Chromosome 5q35 Deletion Syndrome

  • Sotos Syndrome 1, Formerly

  • Sotos1, Formerly

  • Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development

  • Sotos Sequence

  • Sotos' Syndrome

  • Sotos1

  • Sotos Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-105172 TT-232 Agonist 98.72% Phase 2
HY-P0024 Veldoreotide Activator / Phase 2
HY-P1384 L803 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-139347 Mazisotine Agonist 99.54% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.97% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-W1117589 SSTR4 agonist 6 Agonist / Unkown
HY-142701 SSTR4 agonist 4 Activator / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-172147 SSTR4 agonist 5 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SSTR4 MGD MGI:105372
Rattus norvegicus SSTR4 RGD RGD:3764
Felis catus SSTR4 VGNC VGNC:65713
Macaca mulatta SSTR4 VGNC VGNC:77895
Others SSTR4 NCBI