SSTR5 - somatostatin receptor 5 Gene

Homo sapiens

Also known as SST5; SS-5-R

Gene ID: 6755 | Gene type: protein coding

About SSTR5

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,072,747-1,081,454 (from NCBI)

This gene has 2 transcripts (splice variants), 257 orthologues and 17 paralogues. Low expression observed in reference dataset.

Summary

Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]

SSTR5 Products(4)

mRNA	Protein	Name
NM_001053.4	NP_001044.1	somatostatin receptor type 5
NM_001172573.1
NM_001172572.1
NM_001172560.3	NP_001166031.1	somatostatin receptor type 5

SSTR5 Protein Structure

7tm_1

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 5

somatostatin receptor subtype 5

Related Diseases

Diseases

Alias

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor	Pituitary Tumors, Hormone Producing
Somatotropinoma	Growth Hormone-Producing Pituitary Gland Neoplasm

Prolactin Producing Pituitary Tumor

Prolactin-Producing Pituitary Gland Carcinoma	Prolactin-Producing Pituitary Tumor
Malignant Prolactin Producing Neoplasm Of Pituitary Gland	Malignant Prolactinoma
Prolactin Producing Pituitary Tumour	Prolactin Secreting Tumor Of Pituitary
Prolactin Secreting Tumour Of Pituitary

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Fmtc
Mtc1	Thyroid Cancer, Medullary
Medullary Thyroid Cancer	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Islet Cell Tumor

Pancreatic Neuroendocrine Tumor	Neuroendocrine Tumor Of Pancreas
Pnet	Pancreatic Net
Well-Differentiated Nen Of Pancreas	Well-Differentiated Neuroendocrine Neoplasm Of Pancreas
Well-Differentiated Pancreatic Nen	Well-Differentiated Pancreatic Neuroendocrine Neoplasm
Endocrine Pancreas Cancer	Islet Cell Neoplasm
Islet Cell Tumour	Malignant Pancreatic Endocrine Tumor
Malignant Pancreatic Endocrine Tumour	Malignant Tumor Of Endocrine Pancreas
Malignant Tumour Of Endocrine Pancreas	Pancreatic Endocrine Neoplasm
Pancreatic Endocrine Tumor	Pancreatic Neuroendocrine Neoplasm
Adenoma, Islet Cell	Well Differentiated Pancreatic Endocrine Tumor
Malignant Neoplasm Of Endocrine Pancreas	Pancreatic Endocrine Carcinoma

Pituitary Adenoma

Pituitary Neoplasms	Adenoma Of The Pituitary Gland
Pituitary Adenomas	Adenoma, Pituitary
Pituitary Gland Adenoma

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma	Corticotroph Adenoma
Corticotropinoma	Pituitary-Dependent Cushing'S Disease
Adrenal Gland Hyperfunction	Cushing Syndrome

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Tsh Producing Pituitary Tumor

Thyrotroph Adenoma	Tsh Producing Pituitary Tumour
Tsh Secreting Adenoma Of The Pituitary	Tsh Secreting Tumor Of Pituitary
Tsh Secreting Tumour Of Pituitary	Tsh-Secreting Pituitary Adenoma
Pituitary Thyrotrophic Adenoma	Tsh-Oma
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma	Thyroid Stimulating Hormone-Producing Pituitary Tumor

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Pituitary Carcinoma

Pituitary Cancer	Carcinoma Of The Pituitary Gland
Malignant Neoplasm Of Pituitary Gland

Endocrine Organ Benign Neoplasm

Nelson Syndrome

Nelson'S Syndrome	Dermal Ridges
Ridges-Off-The-End Syndrome	Postadrenalectomy Cushing Syndrome

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Hyperpituitarism

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour	Neuroendocrine Tumor Of Esophagus
Neuroendocrine Tumour Of Oesophagus

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung

Gastrinoma

Gastrin Cell Tumour	Gastrin Secreting Tumor
Malignant Gastrinoma	Gastrinoma, Malignant

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Lissencephaly, X-Linked, 2

X-Linked Lissencephaly With Abnormal Genitalia	Hydranencephaly With Abnormal Genitalia
Xlag	Xlisg
X-Linked Lissencephaly With Ambiguous Genitalia	LISX2
Lissencephaly, X-Linked 2	X-Linked Lissencephaly 2
X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome	Xlag Syndrome
Lissencephaly, X-Linked, With Ambiguous Genitalia	Xlis2
X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies	X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome
Xlag Syndrome	Lissencephaly X-Linked With Ambiguous Genitalia
Lissencephaly, X-Linked, Type 2	Chromosome Xq26.3 Duplication Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide	Agonist	99.64%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1203	BIM-23056	Antagonist	99.94%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin 29		99.22%	Unkown
HY-P3124A	BIM-23190 hydrochloride	Agonist	99.64%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P3954	Somatostatin-28 (sheep, human rat mouse)	Inhibitor	/	Unkown
HY-P1203A	BIM-23056 TFA	Antagonist	/	Unkown
HY-P3124	BIM-23190	Agonist	/	Unkown
HY-P2434	AP102		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SSTR5	MGD	MGI:894282
Felis catus	SSTR5	VGNC	VGNC:65714
Canis familiaris	SSTR5	VGNC	VGNC:46846
Rattus norvegicus	SSTR5	RGD	RGD:3765
Bos taurus	SSTR5	VGNC	VGNC:35328
Macaca mulatta	SSTR5	VGNC	VGNC:99596

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