BCL6B - BCL6B transcription repressor Gene

Also Known as BAZF; ZNF62; ZBTB28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 255877

About BCL6B

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,023,050-7,029,644 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 28 paralogues. Broad expression in fat (RPKM 17.2), lung (RPKM 14.1) and 22 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of inflammatory response; and type 2 immune response. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BCL6B Products (1)

mRNA Protein Name
NM_181844.4 NP_862827.2 B-cell CLL/lymphoma 6 member B protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL6B Protein Structure

BTB

BTB: BTB/POZ domain (28 - 134)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (342 - 366)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (370 - 394)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (398 - 423)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (427 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

B-cell CLL/lymphoma 6 member B protein

  • B cell CLL/lymphoma 6B

BCL6B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL6B Q8N143 SULT4A1 Homo sapiens Q9BR01
Anti Tag CoIP
33961781
Intra
BCL6B Q8N143 SULT4A1 Homo sapiens Q9BR01
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178683 ALV-05-077-01 / Unkown
HY-178700 ALV-05-151-02 / Unkown
HY-RS01439 BCL6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BCL6B MGD MGI:1278332
Bos taurus BCL6B VGNC VGNC:57982
Rattus norvegicus BCL6B RGD RGD:1563179
Macaca mulatta BCL6B VGNC VGNC:70037
Canis familiaris BCL6B VGNC VGNC:58662
Others BCL6B NCBI