Cpe - carboxypeptidase E Gene

Also Known as Cph; CARBE

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25669

Summary

Enables Carboxypeptidase activity; cobalt ion binding activity; and protein domain specific binding activity. Involved in negative regulation of branching morphogenesis of a nerve and peptide metabolic process. Located in several cellular components, including membrane raft; perikaryon; and secretory granule. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (Carboxypeptidase E). [provided by Alliance of Genome Resources, Apr 2022]

Cpe Products (1)

mRNA Protein Name
NM_013128.2 NP_037260.2 carboxypeptidase E precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IDA
IDA: Inferred from direct assay
2822027 RGD
enables cobalt ion binding IMP
IMP: Inferred from mutant phenotype
2822027 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
2822027 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
19553464 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IMP
IMP: Inferred from mutant phenotype
25426952 RGD
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
25426952 RGD
involved in cellular response to staurosporine IMP
IMP: Inferred from mutant phenotype
25426952 RGD
involved in enkephalin processing IDA
IDA: Inferred from direct assay
6326144 RGD
involved in insulin processing IDA
IDA: Inferred from direct assay
2822027 RGD
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
12829804 RGD
involved in insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
12829804 RGD
involved in negative regulation of branching morphogenesis of a nerve IMP
IMP: Inferred from mutant phenotype
19553464 RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
25426952 RGD
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
29982499 RGD
involved in neuron projection arborization IMP
IMP: Inferred from mutant phenotype
29982499 RGD
involved in peptide catabolic process IDA
IDA: Inferred from direct assay
2822027 RGD
involved in peptide metabolic process IDA
IDA: Inferred from direct assay
16219686 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
2822027 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19166515 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17543468 RGD
located in dense core granule IDA
IDA: Inferred from direct assay
19553464 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
10386951 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
10206965 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17543468 RGD
located in nucleus IDA
IDA: Inferred from direct assay
25426952 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17543468 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
2822027 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
19553464 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carboxypeptidase E

  • carboxypeptidase H

  • enkephalin convertase

  • prohormone-processing carboxypeptidase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-175469 VNT-101 Inhibitor 99.51% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121528 Nilestriol 98.93% Unkown
HY-132169 HCoV-229E-IN-1 Inhibitor 99.16% Unkown
HY-12349 H1PVAT Inhibitor 96.40% Unkown
HY-P11455A Lipopeptide CPE4 TFA 98.69% Unkown
HY-106508 Fendosal Inhibitor 99.82% Unkown
HY-124938 ABC-1 / Unkown
HY-180578 MWAC-3429 Inhibitor / Unkown
HY-182731 Brain CPE / Unkown
HY-N18293 Makisterone A 2-acetate Control / Unkown
HY-P11455 Lipopeptide CPE4 / Unkown
HY-P11785 Cpe30 MT2 Ligand / Unkown
HY-RS03090 CPE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174385 SARS-CoV-2-IN-114 Inhibitor / Unkown
HY-180525 PB2-IN-2 Inhibitor / Unkown
HY-RS17120 Cpe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23565 Cpe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpe NCBI NCBI:1363