Got2 - glutamic-oxaloacetic transaminase 2 Gene

Also Known as mAAT; ASPATA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25721

Summary

Enables several functions, including L-aspartate:2-oxoglutarate aminotransferase activity; anion binding activity; and identical protein binding activity. Involved in several processes, including dicarboxylic acid metabolic process; lactation; and response to morphine. Located in several cellular components, including T-tubule; mitochondrial inner membrane; and perikaryon. Part of protein-containing complex. Biomarker of acute kidney failure; neurodegenerative disease; obesity; and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Got2 Products (1)

mRNA Protein Name
NM_013177.2 NP_037309.1 aspartate aminotransferase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
10395949 RGD
enables L-aspartate:2-oxoglutarate aminotransferase activity IMP
IMP: Inferred from mutant phenotype
12686151 RGD
enables amino acid binding IDA
IDA: Inferred from direct assay
14522984 RGD
enables carboxylic acid binding IDA
IDA: Inferred from direct assay
14522984 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
3997814 RGD
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
12686151 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
3997814 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
14522984 RGD
enables pyridoxal phosphate binding IMP
IMP: Inferred from mutant phenotype
12686151 RGD
Biological Process GO Annotation Evidence References Source
involved in L-glutamate biosynthetic process IDA
IDA: Inferred from direct assay
16489927 RGD
involved in amino acid metabolic process IDA
IDA: Inferred from direct assay
14522984 RGD
involved in aspartate metabolic process IMP
IMP: Inferred from mutant phenotype
12686151 RGD
involved in dicarboxylic acid metabolic process IDA
IDA: Inferred from direct assay
14522984 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
27317891 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
28798692 RGD
involved in oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
16489927 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
23743348 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
22028411 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
23743348 RGD
located in cell surface IDA
IDA: Inferred from direct assay
11962739 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
3997814 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
7838383 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
3997814 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
23743348 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartate aminotransferase, mitochondrial

  • FABP-1

  • FABPpm

  • Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2)

  • fatty acid-binding protein

  • glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

  • kynurenine aminotransferase 4

  • kynurenine a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05606 GOT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17809 Got2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24277 Got2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Got2 NCBI NCBI:2806