FDCSP - follicular dendritic cell secreted protein Gene

Also Known as C4orf7; FDC-SP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 260436

About FDCSP

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,226,124-70,235,252 (from NCBI)

This gene has 1 transcript (splice variant) and 44 orthologues. Biased expression in salivary gland (RPKM 447.2), lymph node (RPKM 235.7) and 1 other tissue.

Summary

This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting Cancer cell migration and invasion. [provided by RefSeq, Dec 2011]

FDCSP Products (1)

mRNA	Protein	Name
NM_152997.4	NP_694542.1	follicular dendritic cell secreted peptide precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FDCSP Protein Structure

FDC-SP

0
85 a.a.

Protein Preferred Names	Protein Names
follicular dendritic cell secreted peptide	FDC secreted protein

FDCSP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FDCSP	Q8NFU4	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	FDCSP	Q8NFU4	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	FDCSP	Q8NFU4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	FDCSP	Q8NFU4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Follicular Dendritic Cell Sarcoma	Dendritic Cell Sarcoma Dendritic Cell Sarcoma, Follicular Follicular Dendritic Cell Tumour Dendritic Cell Sarcoma, Interdigitating Dendritic Cell Sarcoma, Not Otherwise Specified
Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia	Junctional Epidermolysis Bullosa With Pyloric Atresia Carmi Syndrome Epidermolysis Bullosa, Junctional, With Pyloric Atresia Jeb-Pa JEB5B Epidermolysis Bullosa Junctionalis With Pyloric Atresia Aplasia Cutis Congenita With Gastrointestinal Atresia Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita Eb-Pa-Acc Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome Jeb With Pyloric Atresia Epidermolysis Bullosa Letalis, With Pyloric Atresia Pa-Jeb Epidermolysis Bullosa With Pyloric Atresia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04851	FDCSP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FDCSP	RGD	RGD:1359468
Others	FDCSP	NCBI