Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

Also Known as ASK; ASK1; Mekk5; MAPKKK5; 7420452D20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26408

About Map3k5

Chromosome 10: 19,810,218-20,018,499 forward strand.GRCm39:CM001003.3

This gene has 6 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bladder adult (RPKM 5.2), cortex adult (RPKM 2.8) and 28 other tissues.

Summary

Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and positive regulation of cell death. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intracellular signal transduction; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map3k5 Products (2)

mRNA	Protein	Name
NM_008580.4	NP_032606.4	mitogen-activated protein kinase kinase kinase 5
NM_008580.4	NP_032606.4	mitogen-activated protein kinase kinase kinase 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	18948261	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11959862	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18948261	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to reactive nitrogen species	IMP IMP: Inferred from mutant phenotype	18007661	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	12050113	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress	IDA IDA: Inferred from direct assay	18948261	MGI
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12050113	MGI
involved in p38MAPK cascade	IEP IEP: Inferred from expression pattern	22337877	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	12050113	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15767678	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	18948261	MGI
involved in positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	22337877	MGI
acts upstream of or within programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	18007661	MGI
acts upstream of or within regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	19451227	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	12050113	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map3k5 Protein Structure

DUF4071

ASK_PH

STKc_ASK

0
300
600
900
1200
1380 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 5	ASK-1 MAPK/ERK kinase kinase 5 MEK kinase 5 MEKK 5 apoptosis signal-regulating kinase 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08058	MAP3K5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08059	Map3k5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08060	Map3k5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k5	NCBI	NCBI:4217