2. Gene
  3. Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ASK; ASK1; Mekk5; MAPKKK5; 7420452D20Rik

Gene ID: 26408 | Gene type: protein coding

About Map3k5

Chromosome 10: 19,810,218-20,018,499 forward strand.GRCm39:CM001003.3

This gene has 6 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bladder adult (RPKM 5.2), cortex adult (RPKM 2.8) and 28 other tissues.

Summary

Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and positive regulation of cell death. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intracellular signal transduction; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map3k5 Products(1)

mRNA Protein Name
NM_008580.4 NP_032606.4 mitogen-activated protein kinase kinase kinase 5

Map3k5 Protein Structure

DUF4071

DUF4071: pfam13281 (171 - 551)

ASK_PH

ASK_PH: pfam19039 (561 - 660)

STKc_ASK

STKc_ASK: cd06624 (677 - 944)

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  • 1380 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 5

ASK-1

MAPK/ERK kinase kinase 5

MEK kinase 5

MEKK 5

apoptosis signal-regulating kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08058 MAP3K5 Human Pre-designed siRNA Set A / Unkown
HY-RS08059 Map3k5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08060 Map3k5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k5 NCBI NCBI:4217