Map4k1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

Also Known as Hpk1; mHPK1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26411

About Map4k1

Chromosome 7: 28,681,475-28,702,704 forward strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 197 orthologues, 35 paralogues and is associated with 10 phenotypes. Biased expression in spleen adult (RPKM 4.1), thymus adult (RPKM 25.1) and 1 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map4k1 Products (2)

mRNA Protein Name
NM_008279.2 NP_032305.2 mitogen-activated protein kinase kinase kinase kinase 1 isoform 1
NM_001355054.1 NP_001341983.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 2

Map4k1 Protein Structure

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (15 - 273)

CNH

CNH: smart00036 (505 - 812)

  • 0
  • 200
  • 400
  • 600
  • 827 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

  • HPK

  • MAPK/ERK kinase kinase kinase 1

  • MEK kinase kinase 1

  • MEKKK 1

  • hematopoietic progenitor kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138568 HPK1-IN-3 Inhibitor 98.61% Unkown
HY-138742 HPK1-IN-7 Inhibitor 99.11% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149056 GNE-6893 Inhibitor 99.94% Unkown
HY-170443 PF-07265028 Inhibitor 98.04% Unkown
HY-143868 HPK1-IN-27 Inhibitor / Unkown
HY-143871 HPK1-IN-30 Inhibitor / Unkown
HY-156509 HPK1-IN-38 Inhibitor / Unkown
HY-169199 BAY-405 Inhibitor / Unkown
HY-RS08071 MAP4K1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08072 Map4k1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08073 Map4k1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160940 HPK1-IN-46 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k1 NCBI NCBI:11184