Mapk10 - mitogen-activated protein kinase 10 Gene

Also Known as JNK3; Serk2; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); C230008H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26414

About Mapk10

Chromosome 5: 103,055,814-103,359,200 reverse strand.GRCm39:CM000998.3

This gene has 13 transcripts (splice variants), 223 orthologues, 19 paralogues and is associated with 8 phenotypes. Biased expression in cortex adult (RPKM 28.), frontal lobe adult (RPKM 2.7) and 7 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Mapk10 Products (25)

mRNA Protein Name
NM_001407592.1 NP_001394521.1 mitogen-activated protein kinase 10 isoform 5
NM_001407578.1 NP_001394507.1 mitogen-activated protein kinase 10 isoform 3
NM_001310686.3 NP_001297615.1 mitogen-activated protein kinase 10 isoform 5
NM_001407576.1 NP_001394505.1 mitogen-activated protein kinase 10 isoform 8
NM_001407577.1 NP_001394506.1 mitogen-activated protein kinase 10 isoform 3
NM_001310685.2 NP_001297614.1 mitogen-activated protein kinase 10 isoform 4
NM_001407599.1 NP_001394528.1 mitogen-activated protein kinase 10 isoform 12
NM_001081567.3 NP_001075036.1 mitogen-activated protein kinase 10 isoform 1
NM_001407579.1 NP_001394508.1 mitogen-activated protein kinase 10 isoform 3
NM_001407584.1 NP_001394513.1 mitogen-activated protein kinase 10 isoform 2
NM_001318102.1 NP_001305031.1 mitogen-activated protein kinase 10 isoform 1x
NM_001407573.1 NP_001394502.1 mitogen-activated protein kinase 10 isoform 1
NM_001407572.1 NP_001394501.1 mitogen-activated protein kinase 10 isoform 7
NM_009158.4 NP_033184.2 mitogen-activated protein kinase 10 isoform 2
NM_001318131.2 NP_001305060.1 mitogen-activated protein kinase 10 isoform 6
NM_001310683.2 NP_001297612.1 mitogen-activated protein kinase 10 isoform 3
NM_001407595.1 NP_001394524.1 mitogen-activated protein kinase 10 isoform 5
NM_001407574.1 NP_001394503.1 mitogen-activated protein kinase 10 isoform 1
NM_001407588.1 NP_001394517.1 mitogen-activated protein kinase 10 isoform 10
NM_001407586.1 NP_001394515.1 mitogen-activated protein kinase 10 isoform 9
NM_001407601.1 NP_001394530.1 mitogen-activated protein kinase 10 isoform 14
NM_001407575.1 NP_001394504.1 mitogen-activated protein kinase 10 isoform 1
NM_001407589.1 NP_001394518.1 mitogen-activated protein kinase 10 isoform 11
NM_001407600.1 NP_001394529.1 mitogen-activated protein kinase 10 isoform 13
NM_001407580.1 NP_001394509.1 mitogen-activated protein kinase 10 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase activity IDA
IDA: Inferred from direct assay
9349820 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10471813 MGI
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
9349820 MGI
involved in locomotor rhythm IMP
IMP: Inferred from mutant phenotype
22441692 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22441692 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22441692 MGI
involved in response to light stimulus IMP
IMP: Inferred from mutant phenotype
22441692 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17724133 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
17724133 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17724133 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk10 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (62 - 397)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 10

  • JNK3 beta1 protein kinase

  • JNK3 beta2 protein kinase

  • MAP kinase 10

  • MAP kinase p49 3F12

  • SAPK/Erk/kinase 2

  • c-Jun N-terminal kinase 3

  • stress-activated protein kinase JNK3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169067 10-Methoxy-canthin-6-one 98.71% Unkown
HY-RS08095 MAPK10 Human Pre-designed siRNA Set A / Unkown
HY-RS08096 Mapk10 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08097 Mapk10 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk10 NCBI NCBI:5602