Nlrc4 - NLR family, CARD domain containing 4 Gene

Also Known as CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; Card12; 9530011P19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268973

Summary

Enables identical protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; protein homooligomerization; and response to bacterium. Acts upstream of or within regulation of apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol. Part of IPAF inflammasome complex. Used to study familial cold autoinflammatory syndrome 4. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc4 Products (1)

mRNA Protein Name
NM_001033367.3 NP_001028539.1 NLR family CARD domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
26449474 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22885697 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
16648852 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
16648852 MGI
involved in detection of bacterium IMP
IMP: Inferred from mutant phenotype
22885697 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15190255 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
16648852 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
16648852 MGI
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
21874021 MGI
involved in pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
16648852 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15190255 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
15190255 MGI
Cellular Component GO Annotation Evidence References Source
part of IPAF inflammasome complex IDA
IDA: Inferred from direct assay
21874021 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22885697 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NLR family CARD domain-containing protein 4

  • caspase recruitment domain family, member 12

  • caspase recruitment domain-containing protein 12

  • ice protease-activating factor

Nlrc4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nlrc4 Q3UP24 Naip5 Mus musculus Q9R016
Pull Down
26449474
Intra
Nlrc4 Q3UP24 Naip5 Mus musculus Q9R016
Anti Tag CoIP
26449474
Intra
Nlrc4 Q3UP24 Naip5 Mus musculus Q9R016
GMS
23765277
Intra
Nlrc4 Q3UP24 Casp1 Mus musculus P29452
Anti Tag CoIP
22885697
Intra
Nlrc4 Q3UP24 Casp1 Mus musculus P29452
FPS
26449474
Cross: Cross-species interaction Intra: Intraspecies interaction

Nlrc4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84624 phospho-NLRC4(Ser-533) Antibody (YA4321) WB, ICC/IF, ELISA Human, Mouse
HY-P84624A phospho-NLRC4(Ser-533) Antibody (YA4321)(PBS only) WB, ICC/IF, ELISA Human, Mouse
HY-P84625 phospho-NLRC4(Ser-533) Antibody (YA4322) ICC/IF, FC, ELISA Human
HY-P84625A phospho-NLRC4(Ser-533) Antibody (YA4322)(PBS only) ICC/IF, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169996 NP3-253 Inhibitor 99.78% Unkown
HY-152670 JC2-11 Inhibitor 98.03% Unkown
HY-148258 GDC-2394 Inhibitor 99.87% Unkown
HY-N1939 Icariside I 98.76% Unkown
HY-144223 NLRP3-IN-94 Inhibitor 99.93% Unkown
HY-RS09347 NLRC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148258A GDC-2394 sodium Inhibitor / Unkown
HY-161669 NLRP3-IN-40 Inhibitor / Unkown
HY-170233 NLRP3-IN-75 Inhibitor / Unkown
HY-175814 NLRP3-IN-83 Inhibitor / Unkown
HY-178953 NLRP3-IN-84 Inhibitor / Unkown
HY-183337 ZM734 Inhibitor / Unkown
HY-RS17988 Nlrc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24459 Nlrc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrc4 NCBI NCBI:58484