Casp1 - caspase 1 Gene

Mus musculus

Also known as ICE; Il1bc

Gene ID: 12362 | Gene type: protein coding

About Casp1

Chromosome 9: 5,298,508-5,307,290 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 456 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 2.2) and 13 other tissues.

Summary

Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 Products(1)

mRNA	Protein	Name
NM_009807.2	NP_033937.2	caspase-1

Casp1 Protein Structure

CARD_CASP1-like

CASc

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

caspase-1

CASP-1	IL-1 beta-converting enzyme
IL-1B converting enzyme	IL-1BC
interleukin-1 beta convertase	interleukin-1 beta-converting enzyme
p45

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150536	EP39	Inhibitor	/	Unkown
HY-RS01941	CASP1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01942	Casp1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01943	Casp1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp1	NCBI	NCBI:834

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