Casp1 - caspase 1 Gene

Also Known as ICE; Il1bc

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12362

About Casp1

Chromosome 9: 5,298,508-5,307,290 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 456 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 2.2) and 13 other tissues.

Summary

Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 Products (1)

mRNA Protein Name
NM_009807.2 NP_033937.2 caspase-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
18667412 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
18490713 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8670890 MGI
Biological Process GO Annotation Evidence References Source
involved in AIM2 inflammasome complex assembly IDA
IDA: Inferred from direct assay
23567559 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
29887864 MGI
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
35705808 MGI
acts upstream of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
19158679 MGI
acts upstream of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
23028046 MGI
acts upstream of or within mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
23028046 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16585594 MGI
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
21147462 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
27270401 MGI
acts upstream of or within positive regulation of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
21147462 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within programmed necrotic cell death IDA
IDA: Inferred from direct assay
16429160 MGI
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
21147462 MGI
involved in protein maturation IDA
IDA: Inferred from direct assay
32109412 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
11016935 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
14663141 MGI
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
21147462 MGI
acts upstream of or within pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
22002608 MGI
acts upstream of or within regulation of autophagy IMP
IMP: Inferred from mutant phenotype
24581500 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22297845 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
24581500 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
14663141 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
16301672 MGI
Cellular Component GO Annotation Evidence References Source
part of IPAF inflammasome complex IDA
IDA: Inferred from direct assay
21874021 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
21147462 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
35705808 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
15190255 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp1 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 86)

CASc

CASc: smart00115 (151 - 399)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

caspase-1

  • CASP-1

  • IL-1 beta-converting enzyme

  • IL-1B converting enzyme

  • IL-1BC

  • interleukin-1 beta convertase

  • interleukin-1 beta-converting enzyme

  • p45

Casp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Casp1 P29452 sctE1 Salmonella typhi Q56134
Pull Down
10051653
Cross
Casp1 P29452 sctE1 Salmonella typhi Q56134
CoIP
10051653
Intra
Casp1 P29452 Pycard Mus musculus Q9EPB4
Crosslink
27993998
Intra
Casp1 P29452 Pycard Mus musculus Q9EPB4
Anti Bait CoIP
25605870
Intra
Casp1 P29452 Pycard Mus musculus Q9EPB4
Anti Bait CoIP
27993998
Intra
Casp1 P29452 Nlrp3 Mus musculus Q8R4B8
Crosslink
27993998
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N0842 Bevirimat Inhibitor 99.82% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171006 IRF1-IN-1 Inhibitor 99.72% Unkown
HY-171007 IRF1-IN-2 99.83% Unkown
HY-78036 Mesaconic acid Inhibitor 99.95% Unkown
HY-RS01942 Casp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-78036R Mesaconic acid (Standard) Inhibitor / Unkown
HY-150536 EP39 Inhibitor / Unkown
HY-179348 DPP9-IN-2 / Unkown
HY-181132 dCASP1-55 / Unkown
HY-183739 CQ31 / Unkown
HY-P11596 NOTA-Asp2-αvβ6L / Unkown
HY-RS01941 CASP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01943 Casp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp1 NCBI NCBI:834