FETUB - fetuin B Gene

Also Known as 16G2; Gugu; IRL685

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26998

About FETUB

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,635,969-186,653,141 (from NCBI)

This gene has 8 transcripts (splice variants), 268 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 42.7).

Summary

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine Protease Inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the Insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

FETUB Products (9)

mRNA	Protein	Name
NM_001308077.4	NP_001295006.1	fetuin-B isoform 2 precursor
NM_001308079.4	NP_001295008.1	fetuin-B isoform 3 precursor
NM_001375587.2	NP_001362516.1	fetuin-B isoform 1 precursor
NM_001375588.2	NP_001362517.1	fetuin-B isoform 5
NM_001375589.2	NP_001362518.1	fetuin-B isoform 6
NM_001375590.2	NP_001362519.1	fetuin-B isoform 6
NM_001375591.2	NP_001362520.1	fetuin-B isoform 6
NM_001375592.2	NP_001362521.1	fetuin-B isoform 6
NM_014375.3	NP_055190.2	fetuin-B isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FETUB Protein Structure

Cystatin

0
100
200
300
382 a.a.

Protein Preferred Names	Protein Names
fetuin-B	fetuin-like protein IRL685

FETUB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FETUB	Q9UGM5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	FETUB	Q9UGM5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	FETUB	Q9UGM5	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	FETUB	Q9UGM5	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	FETUB	Q9UGM5	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	FETUB	Q9UGM5	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	FETUB	Q9UGM5	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	FETUB	Q9UGM5	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	FETUB	Q9UGM5	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	FETUB	Q9UGM5	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	FETUB	Q9UGM5	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	FETUB	Q9UGM5	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	FETUB	Q9UGM5	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FETUB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70930	Fetuin B Protein, Human (HEK293, His)	Q9UGM5-1 (C16-P382)	≥ 95%, as determined by reducing SDS-PAGE.

FETUB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86882	Fetuin B Antibody (YA6575)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Encephalitozoonosis	Infection By Encephalitozoon
Caffey Disease	Infantile Cortical Hyperostosis CAFYD Cortical Congenital Hyperostosis Caffey-Silverman Syndrome De Toni-Caffey Disease Hyperostosis Cortical Infantile Hyperostosis, Cortical, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04868	FETUB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19001	Fetub Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25490	Fetub Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FETUB	VGNC	VGNC:40826
Rattus norvegicus	FETUB	RGD	RGD:69293
Felis catus	FETUB	VGNC	VGNC:62233
Mus musculus	FETUB	MGD	MGI:1890221
Bos taurus	FETUB	VGNC	VGNC:28955
Macaca mulatta	FETUB	VGNC	VGNC:72638
Others	FETUB	NCBI