IL36A - interleukin 36 alpha Gene

Also Known as FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27179

About IL36A

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,005,459-113,011,072 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues and 7 paralogues. Restricted expression toward esophagus (RPKM 90.8).

Summary

The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal Cancer patients. [provided by RefSeq, Nov 2015]

IL36A Products (1)

mRNA Protein Name
NM_014440.3 NP_055255.1 interleukin-36 alpha

IL36A Protein Structure

IL1

IL1: Interleukin-1 / 18 (51 - 152)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

interleukin-36 alpha

  • FIL1 epsilon

Recombinant IL36A Proteins

Cat. No. 상품명 Accession Purity
HY-P70702 IL-36 alpha/IL-1F6 Protein, Human Q9UHA7 (K6-F158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71857 IL-36 alpha/IL-1F6 Protein, Human (158a.a) Q9UHA7 (M1-F158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700126AF Animal-Free IL-36 alpha/IL-1F6 Protein, Human (His) Q9UHA7 (K6-F158) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Psoriasis
Impetigo Herpetiformis
Pustulosis Of Palm And Sole

  • Psoriasis

  • Acropustulosis

  • Palmoplantar Pustulosis

  • Pustular Psoriasis Of The Palms And/Or Soles

  • Pustulosis Of Palms And Soles

  • Acrodermatitis Continua Of Hallopeau

  • Generalized Pustular Psoriasis
Psoriasis 14, Pustular

  • Generalized Pustular Psoriasis

  • Gpp

  • Ditra

  • Acrodermatitis Continua Of Hallopeau

  • Palmoplantar Pustulosis

  • PSORS14

  • Interleukin 36 Receptor Antagonist Deficiency

  • Psorp

  • Pustular Psoriasis 14

  • Deficiency Of Il-36r Antagonist

  • Acute Generalised Pustular Psoriasis

  • Deficiency Of The Interleukin-36 Receptor Antagonist

  • Generalized Pustular Psoriasis Of Von Zumbusch

  • Von Zumbusch Psoriasis

  • Deficiency Of Il-36ra

  • Psoriasis, Pustular, Generalized

  • Psoriasis, Pustular, Type 14

  • Pustulosis Of Palms And Soles

  • Acute Generalized Pustular Psoriasis

  • Palmoplantar Pustular Psoriasis

  • Pustulosis Palmaris Et Plantaris

  • Ppp - [Palmoplantar Pustulosis]

  • Pustular Psoriasis Of The Palms And Soles

  • Pustular Bacterid
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS06759 IL36A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20963 Il36a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27480 Il36a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL36A VGNC VGNC:59221
Rattus norvegicus IL36A RGD RGD:1306869
Macaca mulatta IL36A VGNC VGNC:73602
Mus musculus IL36A MGD MGI:1859324
Others IL36A NCBI