GNG7 - G protein subunit gamma 7 Gene

Also Known as HG3B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2788

About GNG7

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,511,219-2,702,694 (from NCBI)

This gene has 2 transcripts (splice variants), 178 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 18.8), heart (RPKM 10.5) and 22 other tissues.

Summary

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of Adenylate Cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GNG7 Products (1)

mRNA Protein Name
NM_052847.3 NP_443079.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG7 Protein Structure

G-gamma

G-gamma: GGL domain (5 - 68)

  • 0
  • 68 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

  • guanine nucleotide binding protein (G protein), gamma 7

GNG7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNG7 O60262 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
GNG7 O60262 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
GNG7 O60262 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05560 GNG7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GNG7 VGNC VGNC:29468
Canis familiaris GNG7 VGNC VGNC:41322
Mus musculus GNG7 MGD MGI:95787
Rattus norvegicus GNG7 RGD RGD:61860
Others GNG7 NCBI