FGFR1 - fibroblast growth factor receptor 1 Gene

Bos taurus

Gene ID: 281768 | Gene type: protein coding

About FGFR1

Primary_assembly 27: 33,549,267-33,599,083 reverse strand.ARS-UCD1.2:CM008194.2

This gene has 6 transcripts (splice variants), 293 orthologues and 56 paralogues.

FGFR1 Products(1)

mRNA	Protein	Name
NM_001110207.1	NP_001103677.1	fibroblast growth factor receptor 1 precursor

FGFR1 Protein Structure

IgI_1_FGFR

IgI_2_FGFR

IgI_3_FGFR

PTKc_FGFR1

0
200
400
600
824 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 1

fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)

Related Agents

Approval

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-50904	Nintedanib	Inhibitor	99.94%	Yes
HY-18708	Erdafitinib		99.66%	Unkown
HY-12047	Ponatinib		99.67%	Yes
HY-13311	Infigratinib		99.82%	Yes
HY-10208	Pazopanib		99.91%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-N0060	Ferulic acid	Inhibitor	99.97%	Yes
HY-100818	Futibatinib	Inhibitor	99.90%	Unkown
HY-11106	Nintedanib esylate	Inhibitor	99.96%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.91%	Yes
HY-12297	Sulfatinib	Inhibitor	99.52%	Unkown
HY-108766	Ponatinib hydrochloride		99.76%	Yes
HY-12009	Pazopanib Hydrochloride		99.99%	Yes
HY-13311A	Infigratinib phosphate	Inhibitor	99.59%	Yes
HY-N0060A	Ferulic acid sodium	Inhibitor	99.88%	Yes

Clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101296	PD-166866		99.75%	Phase 4
HY-13330	Fexagratinib	Inhibitor	99.92%	Phase 3
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-19981	Derazantinib	Inhibitor	99.41%	Phase 3
HY-10517	Orantinib		99.29%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-145601	Tinengotinib	Inhibitor	99.57%	Phase 3
HY-15391	Lucitanib	Inhibitor	98.94%	Phase 3
HY-10337	Brivanib		99.92%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-10336	Brivanib (alaninate)		99.45%	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-16135	CEP-11981	Inhibitor	99.88%	Phase 2
HY-13304	LY2874455	Inhibitor	99.14%	Phase 2
HY-10987A	ENMD-2076		99.99%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-109082	Cevidoplenib	Inhibitor	99.58%	Phase 2
HY-10987	ENMD-2076 Tartrate		99.66%	Phase 2
HY-19981B	Derazantinib dihydrochloride	Inhibitor	/	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-16135A	CEP-11981 tosylate	Inhibitor	/	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-12624	Narazaciclib	Inhibitor	98.66%	Phase 1
HY-100491	H3B-6527	Inhibitor	98.0%	Phase 1
HY-19983	ASP5878	Inhibitor	99.69%	Phase 1
HY-101768	PRN1371	Inhibitor	99.78%	Phase 1
HY-156632	Resigratinib	Inhibitor	99.53%	Phase 1
HY-100315	XL 999	Inhibitor	99.01%	Phase 1
HY-131908	CPL304110	Inhibitor	99.85%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99614	Fazpilodemab	Agonist	99.99%	Phase 2

Pre-clinical Phase

Bioactive Molecules (141)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10321	PD173074		99.86%	Unkown
HY-10407	SU 5402	Inhibitor	99.78%	Unkown
HY-P5321	bFGF (119-126)	Inhibitor	99.93%	Unkown
HY-147250	Lirafugratinib	Inhibitor	99.67%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-108628	SU16f	Inhibitor	99.36%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-N5112A	β,β-Dimethylacrylalkannin		99.36%	Unkown
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-101466	E7090	Inhibitor	98.11%	Unkown
HY-136605	DGY-06-116	Inhibitor	98.62%	Unkown
HY-15590	AZ-23	Inhibitor	98.92%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-100434	PD-161570	Inhibitor	99.82%	Unkown
HY-102071	KIN59	Inhibitor	99.0%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.76%	Unkown
HY-N7715	Ferulic acid acyl-β-D-glucoside		99.33%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.16%	Unkown
HY-137967	Genistein 7-β-D-Glucuronide		98.76%	Unkown
HY-114311	FGFR1/DDR2 inhibitor 1	Inhibitor	98.26%	Unkown
HY-156019	FGFR1 inhibitor-10	Inhibitor	98.31%	Unkown
HY-118203	SU4984	Inhibitor	99.70%	Unkown
HY-W007587	9-Bromononanoic acid		98.0%	Unkown
HY-147250A	Lirafugratinib hydrochloride	Inhibitor	98.96%	Unkown
HY-16025	EOC317	Inhibitor	98.01%	Unkown
HY-133980A	O-Demethyl Lenvatinib hydrochloride		97.08%	Unkown
HY-163705	BR-cpd7	Degrader	98.01%	Unkown
HY-50904S2	Nintedanib-d8	Inhibitor	99.90%	Unkown
HY-60218	1-Boc-3-(hydroxymethyl)pyrrolidine		97.86%	Unkown
HY-18603	FIIN-3	Inhibitor	99.01%	Unkown
HY-175743	TYRA-200	Inhibitor	98.06%	Unkown
HY-10981S	Lenvatinib-d4	Inhibitor	99.59%	Unkown
HY-176862A	TCB-32 hydrochloride		/	Unkown
HY-RS04911	FGFR1 Human Pre-designed siRNA Set A		/	Unkown
HY-10517A	(Z)-Orantinib	Inhibitor	99.44%	Unkown
HY-108933	JK-P3	Inhibitor	99.75%	Unkown
HY-15599	SSR128129E	Inhibitor	99.18%	Unkown
HY-162153	CYY292	Inhibitor	99.19%	Unkown
HY-15391A	Lucitanib dihydrochloride	Inhibitor	98.12%	Unkown
HY-12965	S49076	Inhibitor	99.44%	Unkown
HY-13737	R1530		99.06%	Unkown
HY-112345	PD-089828	Inhibitor	98.07%	Unkown
HY-164853	Kanglexin	Inhibitor	99.65%	Unkown
HY-165298	DGY-09-192		99.50%	Unkown
HY-50904S1	Nintedanib-13C,d3	Inhibitor	99.84%	Unkown
HY-P3281	FGL peptide	Activator	99.69%	Unkown
HY-RS04912	Fgfr1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-19981A	Derazantinib Racemate	Inhibitor	99.38%	Unkown
HY-10208S	Pazopanib-d6		98.0%	Unkown
HY-12009S	Pazopanib-13C,d3 hydrochloride		97.51%	Unkown
HY-12047S	Ponatinib-d8		99.16%	Unkown
HY-13311S	Infigratinib-d3	Inhibitor	98.90%	Unkown
HY-133980	O-Demethyl Lenvatinib		/	Unkown
HY-145043	FGFR-IN-1	Inhibitor	99.46%	Unkown
HY-176862	TCB-32		/	Unkown
HY-50904S	Nintedanib-d3	Inhibitor	/	Unkown
HY-RS04913	Fgfr1 Rat Pre-designed siRNA Set A		/	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-12965A	S49076 hydrochloride	Inhibitor	/	Unkown
HY-10407G	SU 5402 (GMP)	Inhibitor	/	Unkown
HY-183960	BPyO-34	Inhibitor	/	Unkown
HY-101544	ARQ 069	Inhibitor	/	Unkown
HY-10208S1	Pazopanib-13C,d3		/	Unkown
HY-10335	BMS-645737	Inhibitor	/	Unkown
HY-10981S1	Lenvatinib-d5	Inhibitor	/	Unkown
HY-10981S2	Lenvatinib-15N,d4	Inhibitor	98.01%	Unkown
HY-115541	BRD4-IN-41	Inhibitor	/	Unkown
HY-116059	EGFR-IN-199	Inhibitor	/	Unkown
HY-122833	FGFR3-IN-10	Inhibitor	/	Unkown
HY-122888	MPT0L145		/	Unkown
HY-123134	FIIN-4	Inhibitor	/	Unkown
HY-131244	ALK-IN-9	Inhibitor	/	Unkown
HY-139376	FGFR1 inhibitor-2	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-143272	FGFR1 inhibitor-6	Inhibitor	/	Unkown
HY-146541	FGFR4-IN-10	Inhibitor	/	Unkown
HY-147713	FGFR3-IN-1	Inhibitor	/	Unkown
HY-147715	FGFR3-IN-3	Inhibitor	/	Unkown
HY-148778	FGFR3-IN-4	Inhibitor	/	Unkown
HY-149415	Multi-kinase-IN-5	Inhibitor	/	Unkown
HY-149486	FGFR1 inhibitor 7	Inhibitor	/	Unkown
HY-149487	FGFR1 inhibitor-8	Inhibitor	/	Unkown
HY-149488	FGFR1 inhibitor-9	Inhibitor	/	Unkown
HY-149512	FGFR1/VEGFR2-IN-1	Inhibitor	/	Unkown
HY-150026	Multi-kinase-IN-2		/	Unkown
HY-150652	FGFR-IN-8		/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-151969	VEGFR-2-IN-30	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50		/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-158027	B-Raf IN 17	Inhibitor	/	Unkown
HY-158098	FGFR1 inhibitor-11	Inhibitor	/	Unkown
HY-161841	Antitumor agent-177	Inhibitor	/	Unkown
HY-161995	FGFR1/VEGFR2-IN-2		/	Unkown
HY-162577	FGFR-IN-14	Inhibitor	/	Unkown
HY-163273	FGFR4-IN-17	Inhibitor	/	Unkown
HY-163527	FGFR-IN-13	Inhibitor	/	Unkown
HY-168286	FGFR-IN-16	Inhibitor	/	Unkown
HY-168597	FGFR1/VEGFR2-IN-3		/	Unkown
HY-168653	FGFR-IN-15	Inhibitor	/	Unkown
HY-169623	FGFR1 inhibitor-14	Inhibitor	/	Unkown
HY-170846	FGFRs-IN-1	Inhibitor	/	Unkown
HY-170869	PROTAC FGFR1 degrader-1	Degrader	/	Unkown
HY-170919	FGFR2/3-IN-2	Inhibitor	/	Unkown
HY-170934	BW710	Inhibitor	/	Unkown
HY-172618	FGFR1 inhibitor-18	Inhibitor	/	Unkown
HY-172921	FGFR-IN-18	Inhibitor	/	Unkown
HY-172922	FGFR-IN-19	Inhibitor	/	Unkown
HY-174154	INCB126503	Inhibitor	/	Unkown
HY-177276	FGFR-IN-22	Inhibitor	/	Unkown
HY-178059	FGFR-IN-23		/	Unkown
HY-179381	FGFR4-IN-24	Inhibitor	/	Unkown
HY-181005	FGFR-IN-25		/	Unkown
HY-181031	FGFR-IN-24		/	Unkown
HY-181752	FGFR3-IN-12		/	Unkown
HY-182817	Len-604		/	Unkown
HY-182915	FGFR-IN-26	Inhibitor	/	Unkown
HY-183684	RET-IN-33	Inhibitor	/	Unkown
HY-183780	FGFR-IN-27		/	Unkown
HY-402309	IGF-1R modulator 1	Modulator	/	Unkown
HY-50905S	Dovitinib-d8	Inhibitor	/	Unkown
HY-E70717	FGFR1 V561M Recombinant Human Active Protein Kinase		/	Unkown
HY-N0060S1	Ferulic acid-13C3	Inhibitor	98.3%	Unkown
HY-P10870	Pep1-DNP conjugate 9		/	Unkown
HY-RS04914	FGFR1OP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W758126	(R)-Brivanib alaninate-d4		/	Unkown
HY-W801893	FGFR1 inhibitor-13	Inhibitor	/	Unkown
HY-10208S2	Pazopanib-d3		/	Unkown
HY-123453	SM27	Inhibitor	/	Unkown
HY-15599A	SSR128129E free acid	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-164459	AZ8010	Inhibitor	/	Unkown
HY-169669	FGFR1 inhibitor-17	Inhibitor	/	Unkown
HY-169710	FGFR1 inhibitor-16	Inhibitor	/	Unkown
HY-174690	Human FGFR1 mRNA		/	Unkown
HY-18817	AFG210	Inhibitor	/	Unkown
HY-W261325	FGFR1 inhibitor-15	Inhibitor	/	Unkown
HY-W705479	Pazopanib-d3 hydrochloride		/	Unkown
HY-W754878	Pemigatinib-d6	Inhibitor	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990964	Efimosfermin alfa		99%	Unkown
HY-P991999	OM-RCA-01		≥99.0%	Unkown
HY-P990415	Anti-FGFR1/CD331 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	FGFR1	NCBI	NCBI:2260

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