Mapk15 - mitogen-activated protein kinase 15 Gene

Also Known as Erk7; ERK-8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 286997

About Mapk15

Primary_assembly 7: 107,694,964-107,714,645 forward strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 197 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 39.2), Lung (RPKM 17.6) and 2 other tissues.

Summary

Predicted to enable MAP kinase activity and chromatin binding activity. Involved in several processes, including negative regulation of cellular macromolecule biosynthetic process; positive regulation of protein metabolic process; and response to estradiol. Located in nucleus. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Apr 2022]

Mapk15 Products (1)

mRNA Protein Name
NM_173331.2 NP_775453.1 mitogen-activated protein kinase 15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9880541 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
9891064 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12917323 RGD
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
12917323 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
12917323 RGD
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
12917323 RGD
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
11287416 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9891064 RGD
involved in response to estradiol IMP
IMP: Inferred from mutant phenotype
12917323 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9880541 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk15 Protein Structure

STKc_MAPK15-like

STKc_MAPK15-like: cd07852 (5 - 343)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 583 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 15

  • ERK-7

  • MAP kinase 15

  • MAPK 15

  • extracellular signal-regulated kinase 7

  • extracellular signal-regulated kinase 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135906 CK2/ERK8-IN-1 99.0% Unkown
HY-RS08110 MAPK15 Human Pre-designed siRNA Set A / Unkown
HY-RS08111 Mapk15 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08112 Mapk15 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk15 NCBI NCBI:225689