Ddx5 - DEAD-box helicase 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287765

Summary

Enables several functions, including RNA helicase activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in regulation of viral genome replication. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Apr 2022]

Ddx5 Products (1)

mRNA Protein Name
NM_001007613.1 NP_001007614.1 probable ATP-dependent RNA helicase DDX5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA helicase activity IDA
IDA: Inferred from direct assay
7525583 RGD
enables calcium-dependent protein binding IDA
IDA: Inferred from direct assay
7525583 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
7525583 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
19224332 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17960593 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
19224332 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX5

  • DEAD (Asp-Glu-Ala-Asp) box helicase 5

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

  • ddx5 gene protein

  • p68 RNA helicase

Ddx5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ddx5 Q6AYI1 a0a3g5biy8_sars SARS coronavirus Urbani A0A3G5BIY8
Y2H
19224332
Cross
Ddx5 Q6AYI1 a0a3g5biy8_sars SARS coronavirus Urbani A0A3G5BIY8
Gal4 VP16 Complement
19224332
Cross
Ddx5 Q6AYI1 a0a3g5biy8_sars SARS coronavirus Urbani A0A3G5BIY8
Anti Tag CoIP
19224332
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-168739 Topoisomerase I inhibitor 17 / Phase 2
HY-12486 FL118 99.22% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178226 PBX-7016 Inhibitor / Unkown
HY-160438B PBX-7011 TFA Inhibitor 98.60% Unkown
HY-160438A PBX-7011 mesylate Inhibitor / Unkown
HY-160438 PBX-7011 Inhibitor / Unkown
HY-181018 Topo I/DDX5-IN-1 / Unkown
HY-RS03655 DDX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16886 Ddx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23328 Ddx5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx5 NCBI NCBI:1655