2. Gene
  3. NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 Gene

NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NRMT; NRMT1; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A

Gene ID: 28989 | Gene type: protein coding

About NTMT1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,608,872-129,636,135 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.4), adrenal (RPKM 9.8) and 25 other tissues.

Summary

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A Enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

NTMT1 Products(9)

mRNA Protein Name
NM_001286796.2 NP_001273725.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286797.2 NP_001273726.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286798.2 NP_001273727.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286799.2 NP_001273728.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a
NM_001286800.2 NP_001273729.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286801.2 NP_001273730.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b
NM_001286802.2 NP_001273731.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_001286803.2 NP_001273732.1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c
NM_014064.4 NP_054783.2 N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

NTMT1 Protein Structure

Methyltransf_PK

Methyltransf_PK: AdoMet dependent proline di-methyltransferase (8 - 223)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

N-terminal Xaa-Pro-Lys N-methyltransferase 1

N-terminal RCC1 methyltransferase

Recombinant NTMT1 Proteins

Cat. No. Product Name Accession Purity
HY-P77447 METTL11A Protein, Human Q9BV86 (T2-R223) ≥95%
HY-P77448 METTL11A Protein, Human (GST) Q9BV86 (T2-R223) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09620 NTMT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NTMT1 VGNC VGNC:44006
Bos taurus NTMT1 VGNC VGNC:32303
Felis catus NTMT1 VGNC VGNC:102959
Macaca mulatta NTMT1 VGNC VGNC:75451
Mus musculus NTMT1 MGD MGI:1913867
Rattus norvegicus NTMT1 RGD RGD:1306582
Others NTMT1 NCBI