Dctn1 - dynactin subunit 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29167

Summary

Enables identical protein binding activity and microtubule binding activity. Predicted to be involved in several processes, including microtubule Cytoskeleton organization; plasma membrane bounded cell projection organization; and regulation of microtubule Cytoskeleton organization. Predicted to act upstream of or within melanosome transport. Part of cytoplasmic dynein complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Dctn1 Products (1)

mRNA Protein Name
NM_024130.2 NP_077044.2 dynactin subunit 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25419851 RGD
enables microtubule binding IDA
IDA: Inferred from direct assay
7878030 RGD
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
31445682 RGD
Cellular Component GO Annotation Evidence References Source
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
1828535 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynactin subunit 1

  • 150 kDa dynein-associated polypeptide

  • DAP-150

  • DP-150

  • dynactin 1

  • p150-glued

Dctn1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dctn1 P28023 Hap1 Rattus norvegicus P54256
Confocal
9361024
Intra
Dctn1 P28023 Dctn1 Rattus norvegicus P28023
Pull Down
25419851
Intra
Dctn1 P28023 Hap1 Rattus norvegicus P54256
Anti Bait CoIP
9361024
Intra
Dctn1 P28023 Dctn1 Rattus norvegicus P28023
GMS
25419851
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03593 DCTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19427 Dctn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25918 Dctn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dctn1 NCBI NCBI:1639