Hpca - hippocalcin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29177

Summary

Enables calcium ion binding activity and kinase binding activity. Involved in several processes, including activation of Phospholipase D activity; cellular response to electrical stimulus; and negative regulation of Guanylate Cyclase activity. Located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Is extrinsic component of membrane. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Apr 2022]

Hpca Products (1)

mRNA Protein Name
NM_017122.2 NP_058818.1 neuron-specific calcium-binding protein hippocalcin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
1543495 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
23142228 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16470652 RGD
Biological Process GO Annotation Evidence References Source
involved in activation of phospholipase D activity IDA
IDA: Inferred from direct assay
11211872 RGD
involved in calcium-mediated signaling IEP
IEP: Inferred from expression pattern
20704590 RGD
involved in cellular response to L-glutamate IDA
IDA: Inferred from direct assay
20704590 RGD
involved in cellular response to electrical stimulus IEP
IEP: Inferred from expression pattern
20704590 RGD
involved in negative regulation of guanylate cyclase activity IDA
IDA: Inferred from direct assay
15336960 RGD
involved in positive regulation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
15336960 RGD
involved in positive regulation of phospholipase activity IDA
IDA: Inferred from direct assay
11211872 RGD
involved in positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
23142228 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
20852624 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
20852624 RGD
involved in response to Aroclor 1254 IEP
IEP: Inferred from expression pattern
18602130 RGD
involved in response to L-glutamate IEP
IEP: Inferred from expression pattern
20704590 RGD
involved in response to ketamine IEP
IEP: Inferred from expression pattern
12614903 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18602130 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
7789406 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
7789406 RGD
located in cytosol IDA
IDA: Inferred from direct assay
1543495 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
8233019 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
8233019 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
20704590 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20704590 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20704590 RGD
located in membrane IDA
IDA: Inferred from direct assay
1543495 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
8233019 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
8233019 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
20704590 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
20704590 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuron-specific calcium-binding protein hippocalcin

  • P23K

  • calcium-binding protein

Hpca Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Hpca P84076 PDE1A Bos taurus P14100
Pull Down
16470652
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01791 CACNA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06333 HPCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17810 Hpca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21232 Cacna1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24278 Hpca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpca NCBI NCBI:3208