Tk2 - thymidine kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291824

Summary

Enables deoxycytidine kinase activity and thymidine kinase activity. Involved in deoxycytidine metabolic process and thymidine metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tk2 Products (1)

mRNA Protein Name
NM_001106166.1 NP_001099636.1 thymidine kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables deoxycytidine kinase activity IDA
IDA: Inferred from direct assay
21444706 RGD
enables thymidine kinase activity IDA
IDA: Inferred from direct assay
21444706 RGD
Biological Process GO Annotation Evidence References Source
involved in deoxycytidine metabolic process IDA
IDA: Inferred from direct assay
21444706 RGD
involved in thymidine metabolic process IDA
IDA: Inferred from direct assay
21444706 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thymidine kinase 2

  • thymidine kinase 2, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008907 5'-O-Tritylthymidine Inducer 99.79% Unkown
HY-128710 2'-Fluorothymidine 99.07% Unkown
HY-W353804 2′-Deoxy-β-L-uridine 99.96% Unkown
HY-RS14556 TK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14557 TK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128710R 2'-Fluorothymidine (Standard) / Unkown
HY-RS17628 Tk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24088 Tk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tk2 NCBI NCBI:7084