2′-Deoxy-β-L-uridine
Based on 1 Customer Validation
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 31501-19-6
- Formula: C9H12N2O5
- Molecular Weight:228.20
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 31501-19-6
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Appearance Solid
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Molecular Weight 228.20
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Formula C9H12N2O5
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Color White to off-white
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SMILES
O=C(NC(C=C1)=O)N1[C@@H]2C[C@@H](O)[C@H](CO)O2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 116.67 mg/mL (511.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Spadari S, et al. L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem. 1992 Oct 30;35(22):4214-20. [Content Brief]
[2]. Lin TS, et al. Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro. J Med Chem. 1996 Apr 26;39(9):1757-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3821 mL | 21.9106 mL | 43.8212 mL | 109.5530 mL |
| 5 mM | 0.8764 mL | 4.3821 mL | 8.7642 mL | 21.9106 mL | |
| 10 mM | 0.4382 mL | 2.1911 mL | 4.3821 mL | 10.9553 mL | |
| 15 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
| 20 mM | 0.2191 mL | 1.0955 mL | 2.1911 mL | 5.4777 mL | |
| 25 mM | 0.1753 mL | 0.8764 mL | 1.7528 mL | 4.3821 mL | |
| 30 mM | 0.1461 mL | 0.7304 mL | 1.4607 mL | 3.6518 mL | |
| 40 mM | 0.1096 mL | 0.5478 mL | 1.0955 mL | 2.7388 mL | |
| 50 mM | 0.0876 mL | 0.4382 mL | 0.8764 mL | 2.1911 mL | |
| 60 mM | 0.0730 mL | 0.3652 mL | 0.7304 mL | 1.8259 mL | |
| 80 mM | 0.0548 mL | 0.2739 mL | 0.5478 mL | 1.3694 mL | |
| 100 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0955 mL |
2′-Deoxy-β-L-uridine Related Classifications
HY-W353804 Related Classifications
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