Map4k1 - mitogen activated protein kinase kinase kinase kinase 1 Gene

Also Known as Hpk1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292763

About Map4k1

Primary_assembly 1: 84,271,069-84,292,493 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 197 orthologues, 36 paralogues and is associated with 1 phenotype. Biased expression in Spleen (RPKM 137.9), Thymus (RPKM 92.1) and 4 other tissues.

Summary

Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Used to study transient cerebral ischemia. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map4k1 Products (2)

mRNA Protein Name
NM_001106243.1 NP_001099713.1 mitogen-activated protein kinase kinase kinase kinase 1
NM_001106243.1 NP_001099713.1 mitogen-activated protein kinase kinase kinase kinase 1

Map4k1 Protein Structure

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (15 - 273)

CNH

CNH: smart00036 (505 - 812)

  • 0
  • 200
  • 400
  • 600
  • 827 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

  • hematopoietic progenitor kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138568 HPK1-IN-3 Inhibitor 98.61% Unkown
HY-138742 HPK1-IN-7 Inhibitor 99.11% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149056 GNE-6893 Inhibitor 99.94% Unkown
HY-170443 PF-07265028 Inhibitor 98.04% Unkown
HY-143868 HPK1-IN-27 Inhibitor / Unkown
HY-143871 HPK1-IN-30 Inhibitor / Unkown
HY-156509 HPK1-IN-38 Inhibitor / Unkown
HY-169199 BAY-405 Inhibitor / Unkown
HY-RS08071 MAP4K1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08072 Map4k1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08073 Map4k1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160940 HPK1-IN-46 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k1 NCBI NCBI:11184