Cd46 - CD46 molecule Gene

Also Known as Mcp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29333

Summary

Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Biomarker of acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd46 Products (1)

mRNA Protein Name
NM_019190.1 NP_062063.1 membrane cofactor protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to endopeptidase activity IDA
IDA: Inferred from direct assay
15215199 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of proteolysis IDA
IDA: Inferred from direct assay
15215199 RGD
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
15601919 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16425382 RGD
NOT located in cell surface IDA
IDA: Inferred from direct assay
15601919 RGD
located in cell surface IDA
IDA: Inferred from direct assay
7690370 RGD
located in inner acrosomal membrane IDA
IDA: Inferred from direct assay
15215199 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

membrane cofactor protein

  • CD46 antigen, complement regulatory protein

  • CD46 molecule, complement regulatory protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990586 YS5 98.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02249 CD46 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17880 Cd46 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132031 Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682 / Unkown
HY-171509 Mal-N(Me)-C6-N(Me)-PNU-159682 Inducer / Unkown
HY-P2969 Complement factor I 93.00% Unkown
HY-RS24349 Cd46 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd46 NCBI NCBI:4179