Sox10 - SRY-box transcription factor 10 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29361

Summary

Enables several functions, including DNA-binding transcription activator activity; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to progesterone stimulus; regulation of gene expression; and regulation of nervous system development. Located in cytoplasm and nucleus. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2022]

Sox10 Products (1)

mRNA	Protein	Name
NM_019193.3	NP_062066.1	transcription factor SOX-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9412504	RGD
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	26525805	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10559384	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16582099	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	27466180	RGD
enables promoter-specific chromatin binding	IMP IMP: Inferred from mutant phenotype	22037207	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16214168	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	26525805	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to progesterone stimulus	IEP IEP: Inferred from expression pattern	17478888	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	24403178	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16582099	RGD
involved in negative regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	25536222	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16582099	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10559384	RGD
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	25536222	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9412504	RGD
involved in stem cell differentiation	IEP IEP: Inferred from expression pattern	12691661	RGD
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	25524031	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	27466180	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor SOX-10	SRY (sex determining region Y)-box 10 SRY box 10 SRY-box containing gene 10

Sox10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Sox10	O55170	NMI	Homo sapiens	Q13287	Confocal	16214168
Cross	Sox10	O55170	NMI	Homo sapiens	Q13287	Pull Down	16214168
Cross	Sox10	O55170	NMI	Homo sapiens	Q13287	Y2H	16214168

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-179505	OPN-9652	Inhibitor	98.84%	Unkown
HY-RS13583	SOX10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179559	OPN-9643	Inhibitor	/	Unkown
HY-186262	SH-0029	Inhibitor	/	Unkown
HY-RS18684	Sox10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25170	Sox10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox10	NCBI	NCBI:6663