Ppt1 - palmitoyl-protein thioesterase 1 Gene

Also Known as Ppt

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29411

Summary

Predicted to enable lysophosphatidic acid binding activity; sulfatide binding activity; and thiolester hydrolase activity. Predicted to be involved in several processes, including lysosomal lumen acidification; positive regulation of endocytosis; and protein depalmitoylation. Predicted to act upstream of or within several processes, including grooming behavior; regulation of Phospholipase A2 activity; and visual perception. Located in several cellular components, including lysosome; neuronal cell body; and synaptic vesicle. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ppt1 Products (1)

mRNA Protein Name
NM_022502.2 NP_071947.1 palmitoyl-protein thioesterase 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
12270687 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
12270687 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

palmitoyl-protein thioesterase 1

  • PPT-1

  • palmitoyl-protein hydrolase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride 99.26% Phase 2
HY-137978 Ezurpimtrostat 99.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111621 DC661 99.53% Unkown
HY-120252 ABC44 Inhibitor 98.7% Unkown
HY-170670 DQ661 Inhibitor / Unkown
HY-183351 GN-604 / Unkown
HY-RS11038 PPT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17296 Ppt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23751 Ppt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppt1 NCBI NCBI:5538