Gdf15 - growth differentiation factor 15 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29455

Summary

Enables protein homodimerization activity. Predicted to be involved in several processes, including enzyme linked receptor protein signaling pathway; reduction of food intake in response to dietary excess; and regulation of signal transduction. Predicted to act upstream of or within positive regulation of myoblast fusion. Located in extracellular region. Orthologous to human GDF15 (Growth Differentiation Factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Gdf15 Products (2)

mRNA Protein Name
NM_001411583.1 NP_001398512.1 growth/differentiation factor 15 precursor
NM_019216.3 NP_062089.2 growth/differentiation factor 15 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29046435 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
29046435 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 15

  • GDF-15

Recombinant Gdf15 Proteins

Cat. No. Product Name Accession Purity
HY-P700727 GDF-15 Protein, Rat (His) Q9Z0J6 (S189-A303) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99241 Ponsegromab Inhibitor 99.60% Phase 3
HY-P99100 Visugromab Inhibitor 98.40% Phase 3
HY-P991190 Rilogrotug Inhibitor 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W587486 N-Acetyltaurine Inhibitor 99.91% Unkown
HY-149406 AMPK activator 12 Activator 99.68% Unkown
HY-RS16542 Gdf15 Mouse Pre-designed siRNA Set A Inhibitor / Unkown
HY-RS05352 GDF15 Human Pre-designed siRNA Set A Inhibitor / Unkown
HY-183332 YXX0248 Activator / Unkown
HY-183331 YXX0237 Activator / Unkown
HY-RS22974 Gdf15 Rat Pre-designed siRNA Set A Inhibitor / Unkown
HY-W587486A N-Acetyltaurine hemimagnesium Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99100A Visugromab (Powder) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdf15 NCBI NCBI:9518