Pdia3 - protein disulfide isomerase family A, member 3 Gene

Also Known as ER60; ERp57; Grp58

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29468

About Pdia3

Primary_assembly 3: 108,388,245-108,413,236 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 225 orthologues, 14 paralogues and is associated with 19 phenotypes. Biased expression in Liver (RPKM 638.3), Spleen (RPKM 616.4) and 9 other tissues.

Summary

Enables MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Located in several cellular components, including acrosomal vesicle; mitochondrial intermembrane space; and smooth endoplasmic reticulum. Part of TAP complex. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]

Pdia3 Products (1)

mRNA Protein Name
NM_017319.2 NP_059015.2 protein disulfide-isomerase A3 precursor

Pdia3 Protein Structure

ER_PDI_fam

ER_PDI_fam: cl36828 (30 - 491)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A3

  • 58 kDa glucose-regulated protein

  • 58 kDa microsomal protein

  • ER protein 57

  • ER protein 60

  • ER-60 protease

  • ERp60

  • HIP-70

  • Q-2

  • disulfide isomerase ER-60

  • endoplasmic reticulum resident protein 57

  • endoplasmic reticulum resident protein 60

  • glucose regulated protein, 58 kDa

  • oxidoreductase ERp57

  • p58

  • protein disulfide isomerase associated 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0177 Diosgenin Inhibitor 99.92% Unkown
HY-100432 LOC14 98.0% Unkown
HY-122895 E64FC26 98.48% Unkown
HY-122895A (E/Z)-E64FC26 99.80% Unkown
HY-RS10266 PDIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10267 Pdia3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-170655 PDI-IN-4 Inhibitor / Unkown
HY-P11857 Alkyne-GRWHPM-CONH-NH-CMK Inhibitor / Unkown
HY-RS10268 Pdia3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdia3 NCBI NCBI:2923