Mga - MAX gene associated Gene

Also Known as Mad5; C130042M01Rik; D030062C11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 29808

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Apr 2022]

Mga Products (2)

mRNA Protein Name
NM_001164274.1 NP_001157746.1 MAX gene-associated protein isoform 2
NM_013720.2 NP_038748.2 MAX gene-associated protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10601024 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10601024 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10601024 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10601024 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAX gene-associated protein

  • MAX-interacting protein

  • Max dimerization protein 5

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99222 Teplizumab 99.73% Unkown

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P9966 Enoblituzumab Inhibitor 99.16% Phase 3
HY-P99941 Retifanlimab 96.84% Phase 3
HY-P990027 Izeltabart Inhibitor 98.62% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N3686 D-Arabitol Activator 99.92% Unkown
HY-111614 Melengestrol acetate Activator 99.76% Unkown
HY-N3686S D-Arabitol-13C Activator / Unkown
HY-N3686S1 D-Arabitol-13C-1 Activator / Unkown
HY-N3686S2 D-Arabitol-13C-2 Activator / Unkown
HY-RS08395 MGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08396 MGAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179853 MGA-C13 / Unkown
HY-N13366 3-Methylcrotonyl CoA / Unkown
HY-RS18218 Mga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24695 Mga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mga NCBI NCBI:23269