Tlr6 - toll-like receptor 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 305353

About Tlr6

Primary_assembly 14: 43,362,164-43,375,685 forward strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 190 orthologues, 26 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 83.7), Thymus (RPKM 35.7) and 9 other tissues.

Summary

Enables Lipopeptide binding activity. Involved in several processes, including microglial cell activation; nitric oxide metabolic process; and response to Bacterial lipoprotein. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 2-Toll-like receptor 6 protein complex. Predicted to be integral component of plasma membrane. Used to study Bacterial pneumonia. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in aspergillosis; asthma; infective endocarditis; rhinitis; and tuberculosis. Orthologous to human TLR6 (toll like receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Tlr6 Products (1)

mRNA Protein Name
NM_207604.1 NP_997487.1 toll-like receptor 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lipopeptide binding IMP
IMP: Inferred from mutant phenotype
18353287 RGD
Biological Process GO Annotation Evidence References Source
involved in microglial cell activation IDA
IDA: Inferred from direct assay
16973131 RGD
involved in nitric oxide metabolic process IDA
IDA: Inferred from direct assay
16973131 RGD
involved in response to bacterial lipoprotein IDA
IDA: Inferred from direct assay
16973131 RGD
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
16973131 RGD
involved in toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18353287 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr6 Protein Structure

LRR_RI

LRR_RI: sd00033 (45 - 63)

PLN00113

PLN00113: cl33413 (49 - 539)

PPP1R42

PPP1R42: cl42388 (49 - 170)

LRR_1

LRR_1: sd00031 (64 - 87)

LRR_1

LRR_1: sd00031 (88 - 111)

LRR_1

LRR_1: sd00031 (112 - 132)

LRR_1

LRR_1: sd00031 (133 - 157)

LRR_RI

LRR_RI: sd00033 (368 - 384)

LRR_RI

LRR_RI: sd00033 (389 - 414)

PRK15370

PRK15370: cl33128 (389 - 499)

LRR_RI

LRR_RI: sd00033 (415 - 439)

LRR_RI

LRR_RI: sd00033 (440 - 461)

LRR_RI

LRR_RI: sd00033 (462 - 484)

LRR_RI

LRR_RI: sd00033 (485 - 507)

LRR_RI

LRR_RI: sd00033 (509 - 530)

LRRCT

LRRCT: smart00082 (539 - 593)

TIR

TIR: smart00255 (651 - 790)

  • 0
  • 200
  • 400
  • 600
  • 806 a.a.
Protein Preferred Names Protein Names

toll-like receptor 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10586 Macrophage-activating lipopeptide 2 Activator / Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2036A FSL-1 TFA Agonist 99.81% Unkown
HY-P2036 FSL-1 Agonist 99.22% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr6 NCBI NCBI:10333