Ccr6 - C-C motif chemokine receptor 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308163

About Ccr6

Primary_assembly 1: 52,474,168-52,498,603 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 299 orthologues, 24 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 8.7), Thymus (RPKM 21.) and 1 other tissue.

Summary

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell chemotaxis; and positive regulation of epithelial cell migration. Predicted to be located in cell surface; sperm flagellum; and sperm plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of membranoproliferative glomerulonephritis and transient cerebral ischemia. Orthologous to human CCR6 (C-C motif Chemokine Receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Ccr6 Products (1)

mRNA Protein Name
NM_001013145.1 NP_001013163.1 C-C chemokine receptor type 6

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
19233848 RGD
involved in positive regulation of dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
14673014 RGD
involved in positive regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
19233848 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr6 Protein Structure

7tmA_CCR6

7tmA_CCR6: cd15172 (37 - 64)

7tmA_CCR6

7tmA_CCR6: cd15172 (37 - 317)

7tmA_CCR6

7tmA_CCR6: cd15172 (71 - 96)

7tmA_CCR6

7tmA_CCR6: cd15172 (108 - 138)

7tmA_CCR6

7tmA_CCR6: cd15172 (152 - 174)

7tmA_CCR6

7tmA_CCR6: cd15172 (201 - 230)

7tmA_CCR6

7tmA_CCR6: cd15172 (237 - 267)

7tmA_CCR6

7tmA_CCR6: cd15172 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 6

  • CC chemokine receptor 6

  • chemokine (C-C motif) receptor 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148531 PF-07054894 Inhibitor 99.15% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151435 CCR6 antagonist 1 Antagonist 99.30% Unkown
HY-112701 CCR6 inhibitor 1 Inhibitor 99.60% Unkown
HY-162495 IDOR-1117-2520 Antagonist 99.94% Unkown
HY-162495A (S)-IDOR-1117-2520 Antagonist 99.47% Unkown
HY-176980 CCR6 antagonist 4 Antagonist / Unkown
HY-176979 CCR6 antagonist 3 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr6 NCBI NCBI:1235