Kdm2b - lysine (K)-specific demethylase 2B Gene

Also Known as Cxxc2; Fbl10; PCCX2; Fbxl10; Jhdm1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30841

Summary

The protein encoded by this gene is a H3K36-specific Histone Demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Kdm2b Products (5)

mRNA Protein Name
NM_001003953.2 NP_001003953.1 lysine-specific demethylase 2B isoform 1
NM_001378863.1 NP_001365792.1 lysine-specific demethylase 2B isoform 3
NM_001378864.1 NP_001365793.1 lysine-specific demethylase 2B isoform 4
NM_001378865.1 NP_001365794.1 lysine-specific demethylase 2B isoform 5
NM_013910.2 NP_038938.1 lysine-specific demethylase 2B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21245044 MGI
enables histone H3K36 demethylase activity IDA
IDA: Inferred from direct assay
21540074 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17296600 MGI
Biological Process GO Annotation Evidence References Source
involved in embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in forebrain development IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in fourth ventricle development IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in hindbrain development IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in initiation of neural tube closure IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in lateral ventricle development IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in midbrain development IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in midbrain-hindbrain boundary morphogenesis IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in negative regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21220025 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21540074 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21220025 MGI
acts upstream of or within positive regulation of cell growth IDA
IDA: Inferred from direct assay
21540074 MGI
acts upstream of or within positive regulation of stem cell population maintenance IDA
IDA: Inferred from direct assay
21540074 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
21220025 MGI
involved in third ventricle development IMP
IMP: Inferred from mutant phenotype
21220025 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 2B

  • F-box and leucine-rich repeat protein 10

  • F-box protein FBL10

  • F-box protein containing leucine repeats 10

  • F-box/LRR-repeat protein 10

  • [Histone-H3]-lysine-36 demethylase 1B

  • jmjC domain-containing histone demethylation protein 1B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129079 TFMB-(R)-2-HG Inhibitor 98.26% Unkown
HY-139561 KDM2B-IN-2 99.36% Unkown
HY-139601 KDM2B-IN-4 Inhibitor 99.61% Unkown
HY-148369 U7D-1 99.68% Unkown
HY-139560 KDM2B-IN-1 Inhibitor 99.49% Unkown
HY-RS07210 KDM2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-139600 KDM2B-IN-3 Inhibitor / Unkown
HY-RS16813 Kdm2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23253 Kdm2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm2b NCBI NCBI:84678