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EHD4 - EH domain containing 4 Gene

Also Known as PAST4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30844

About EHD4

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,895,933-41,972,557 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 10 paralogues. Ubiquitous expression in urinary bladder (RPKM 15.6), gall bladder (RPKM 14.3) and 25 other tissues.

Summary

Enables Cadherin binding activity. Involved in endocytic recycling and protein homooligomerization. Located in endoplasmic reticulum and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

EHD4 Products (1)

mRNA	Protein	Name
NM_139265.4	NP_644670.1	EH domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17233914	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytic recycling	IGI IGI: Inferred from genetic interaction	17233914	GOA
involved in protein homooligomerization	IPI IPI: Inferred from physical interaction	17233914	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	17233914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHD4 Protein Structure

Dynamin_N

EF-hand_4

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541 a.a.

Protein Preferred Names	Protein Names
EH domain-containing protein 4	PAST homolog 4

Related Diseases

Diseases	Alias
Ovarian Endometrial Cancer	Endometrioid Neoplasm Of Ovary Malignant Ovarian Endometrioid Tumor Ovarian Endometrioid Neoplasm
Cerebral Creatine Deficiency Syndrome 3	Arginine:Glycine Amidinotransferase Deficiency Agat Deficiency Gatm Deficiency Creatine Deficiency Syndrome Due To Agat Deficiency L-Arginine:Glycine Amidinotransferase Deficiency CCDS3 L-Arginine:Glycine Aminidotransferase Deficiency Deficiency, Cerebral Creatine, Syndrome, Type 3
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158415	ATPase-IN-4	Inhibitor	98.25%	Unkown
HY-RS04224	EHD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16299	Ehd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28675	Ehd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EHD4	VGNC	VGNC:28374
Mus musculus	EHD4	MGD	MGI:1919619
Felis catus	EHD4	VGNC	VGNC:104385
Macaca mulatta	EHD4	VGNC	VGNC:72177
Rattus norvegicus	EHD4	RGD	RGD:628883
Canis familiaris	EHD4	VGNC	VGNC:40248