Nfkb2 - nuclear factor kappa B subunit 2 Gene

Rattus norvegicus

Also known as RGD1307189

Gene ID: 309452 | Gene type: protein coding

About Nfkb2

Primary_assembly 1: 245,165,950-245,173,213 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 124.5), Thymus (RPKM 83.) and 9 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in aging; response to cytokine; and response to lipopolysaccharide. Located in cytosol and nucleus. Used to study Parkinsonism. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb2 Products(1)

mRNA	Protein	Name
NM_001008349.1	NP_001008350.1	nuclear factor NF-kappa-B p100 subunit

Nfkb2 Protein Structure

RHD-n_NFkB2

IPT_NFkappaB

PHA03095

ANK

Death_NFkB2_p100

0
200
400
600
800
898 a.a.

Protein Preferred Names

Protein Names

nuclear factor NF-kappa-B p100 subunit

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3229	SN52	Inhibitor	98.24%	Unkown
HY-149351	NF-κB-IN-10	Inhibitor	/	Unkown
HY-RS09257	NFKB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09258	Nfkb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09259	Nfkb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkb2	NCBI	NCBI:4791

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