Nfkb2 - nuclear factor kappa B subunit 2 Gene

Also Known as RGD1307189

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309452

About Nfkb2

Primary_assembly 1: 245,165,950-245,173,213 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 124.5), Thymus (RPKM 83.) and 9 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in aging; response to cytokine; and response to lipopolysaccharide. Located in cytosol and nucleus. Used to study Parkinsonism. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb2 Products (1)

mRNA Protein Name
NM_001008349.1 NP_001008350.1 nuclear factor NF-kappa-B p100 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18534259 RGD
Biological Process GO Annotation Evidence References Source
involved in response to cytokine IEP
IEP: Inferred from expression pattern
12770614 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12770614 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfkb2 Protein Structure

RHD-n_NFkB2

RHD-n_NFkB2: cd07934 (37 - 220)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (227 - 326)

PHA03095

PHA03095: cl33707 (457 - 703)

ANK

ANK: sd00045 (485 - 522)

ANK

ANK: sd00045 (524 - 555)

ANK

ANK: sd00045 (557 - 584)

ANK

ANK: sd00045 (597 - 628)

ANK

ANK: sd00045 (631 - 663)

ANK

ANK: sd00045 (665 - 696)

Death_NFkB2_p100

Death_NFkB2_p100: cd08798 (772 - 846)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
Protein Preferred Names Protein Names

nuclear factor NF-kappa-B p100 subunit

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0024 Tolterodine 98.61% Yes
HY-90010 Tolterodine tartrate 98.64% Yes
HY-90010R Tolterodine tartrate (Standard) / Unkown

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3229 SN52 Inhibitor 99.31% Unkown
HY-149351 NF-κB-IN-10 Inhibitor / Unkown
HY-A0024S Tolterodine-d14 hydrochloride Substrate 99.0% Unkown
HY-RS09257 NFKB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09258 Nfkb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09259 Nfkb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174568 Human NFKB2 mRNA / Unkown
HY-90010S Tolterodine tartrate-d14 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkb2 NCBI NCBI:4791