Plk4 - polo-like kinase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310344

About Plk4

Primary_assembly 2: 123,802,512-123,820,942 forward strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 9 phenotypes. Biased expression in Thymus (RPKM 13.2), Testes (RPKM 9.1) and 9 other tissues.

Summary

Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including organelle assembly; regulation of cell cycle process; and trophoblast giant cell differentiation. Predicted to be located in several cellular components, including XY body; centriole; and deuterosome. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Plk4 Products (1)

mRNA Protein Name
NM_001395103.1 NP_001382032.1 serine/threonine-protein kinase PLK4

Plk4 Protein Structure

STKc_PLK4

STKc_PLK4: cd14186 (10 - 265)

POLO_box_Plk4_1

POLO_box_Plk4_1: cd13114 (547 - 658)

Plk4_PB2

Plk4_PB2: pfam18409 (659 - 767)

POLO_box_Plk4_3

POLO_box_Plk4_3: cd13116 (838 - 917)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 925 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK4

  • PLK-4

  • serine/threonine-protein kinase Sak

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-149324 SP27 Degrader 98.87% Phase 4
HY-12300 Ocifisertib Inhibitor 99.78% Phase 2
HY-12300B Ocifisertib fumarate Inhibitor 98.69% Phase 2
HY-172737 RP-1664 Inhibitor 98.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18682 Centrinone Inhibitor 98.28% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-18683 Centrinone-B Inhibitor 98.65% Unkown
HY-128493 PLK4-IN-4 Inhibitor 99.89% Unkown
HY-132135 (1E)-CFI-400437 dihydrochloride Inhibitor 98.08% Unkown
HY-149912 CZS-241 Inhibitor / Unkown
HY-12300A Ocifisertib hydrochloride Inhibitor 98.29% Unkown
HY-176734 CZL-S092 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-180111 PLK4-IN-7 Inhibitor / Unkown
HY-134775A PLK4-IN-3 Inhibitor / Unkown
HY-179149 PLK4-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk4 NCBI NCBI:10733