Dll4 - delta like canonical Notch ligand 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311332

Summary

Predicted to enable Notch binding activity. Predicted to be involved in several processes, including cellular response to growth factor stimulus; circulatory system development; and regulation of Notch signaling pathway. Predicted to act upstream of or within angiogenesis; negative regulation of blood vessel endothelial cell migration; and regulation of neurogenesis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2022]

Dll4 Products (1)

mRNA Protein Name
NM_001107760.1 NP_001101230.1 delta-like protein 4 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
28472949 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
30653356 RGD
involved in chondrocyte differentiation IEP
IEP: Inferred from expression pattern
26872979 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
21209419 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-like protein 4

  • delta-like 4

  • delta4

  • drosophila Delta homolog 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99377 Navicixizumab Inhibitor 99.83% Phase 3
HY-P991033 Tovecimig 97.39% Phase 3
HY-P99261 Demcizumab Inhibitor 99.37% Phase 2
HY-P99852 Dilpacimab 96.88% Phase 2
HY-P991423 MEDI0639 Inhibitor 98.78% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122094 Steppogenin Inhibitor 99.49% Unkown
HY-N11709 Theasaponin E1 99.08% Unkown
HY-RS16878 Dll4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03810 DLL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23320 Dll4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99925 Enoticumab Inhibitor 99.64% Unkown
HY-P990252 Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dll4 NCBI NCBI:54567