Ttbk2 - tau tubulin kinase 2 Gene

Predicted to enable Kinesin binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hindbrain development; negative regulation of microtubule depolymerization; and negative regulation of protein localization to microtubule. Predicted to act upstream of or within several processes, including embryonic brain development; nervous system development; and positive regulation of non-motile cilium assembly. Predicted to be located in centriole; cytosol; and intermediate filament Cytoskeleton. Predicted to be active in several cellular components, including ciliary basal body; ciliary transition zone; and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Apr 2022]