Sfn - stratifin Gene

Predicted to enable identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; establishment of skin barrier; and regulation of epidermal cell division. Predicted to act upstream of or within keratinocyte differentiation; negative regulation of keratinocyte proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Apr 2022]