Nrcam - neuronal cell adhesion molecule Gene

Also Known as Bravo; mKIAA0343; C030017F07Rik; C130076O07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 319504

Summary

Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in cell-cell adhesion; nervous system development; and regulation of postsynapse organization. Acts upstream of or within several processes, including neuron development; neuronal action potential propagation; and regulation of neuron projection development. Located in axon; plasma membrane; and synapse. Is integral component of postsynaptic density membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

Nrcam Products (2)

mRNA	Protein	Name
NM_001146031.1	NP_001139503.1	neuronal cell adhesion molecule isoform 2 precursor
NM_176930.4	NP_795904.3	neuronal cell adhesion molecule isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16882004	MGI
enables protein binding involved in heterotypic cell-cell adhesion	IGI IGI: Inferred from genetic interaction	20188654	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in axon guidance	IDA IDA: Inferred from direct assay	12182881	MGI
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	12182881	MGI
involved in central nervous system development	IDA IDA: Inferred from direct assay	12182881	MGI
acts upstream of or within clustering of voltage-gated sodium channels	IMP IMP: Inferred from mutant phenotype	20188654	MGI
acts upstream of or within neuronal action potential propagation	IMP IMP: Inferred from mutant phenotype	14602817	MGI
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	16882004	MGI
acts upstream of or within regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	16701205	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	25143608	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	25143608	MGI
acts upstream of or within retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	16701205	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	14602817	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25143608	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	25143608	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25143608	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16882004	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	25143608	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	25143608	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	25143608	MGI
located in synapse	IDA IDA: Inferred from direct assay	16882004	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuronal cell adhesion molecule	mBravo neuron-glia-CAM-related cell adhesion molecule neuronal surface protein Bravo ng-CAM-related ngCAM-related cell adhesion molecule nr-CAM

Nrcam Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Nrcam	Q810U4	Dlg1	Mus musculus	Q811D0	Y2H Array	16882004
Intra	Nrcam	Q810U4	Dlg1	Mus musculus	Q811D0	Imaging	16882004
Intra	Nrcam	Q810U4	Dlg1	Mus musculus	Q811D0	Pull Down	16882004

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09563	NRCAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20457	Nrcam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26966	Nrcam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrcam	NCBI	NCBI:4897