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smo - smoothened Gene

Also Known as CG11561; Dmel\CG11561; dSmo; Smo; SMO

Species: Drosophila melanogaster

Gene Type: protein coding

Gene ID: 33196

Summary

Enables phosphatidylinositol-4-phosphate binding activity; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including animal organ morphogenesis; negative regulation of G1/S transition of mitotic cell cycle; and segment polarity determination. Located in cilium; dendrite; and neuronal cell body. Is integral component of plasma membrane. Colocalizes with axon. Is expressed in several structures, including anterior ectoderm anlage; ectoderm; epithelium; extended germ band embryo; and wing disc. Used to study primary Bacterial infectious disease. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

smo Products (2)

mRNA	Protein	Name
NM_078719.4	NP_523443.1	smoothened [Drosophila melanogaster]
NM_078719.4	NP_523443.1	smoothened [Drosophila melanogaster]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	37847757	FlyBase
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	26863604	FlyBase
enables protein binding	IPI IPI: Inferred from physical interaction	14597665	FlyBase
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21852395	FlyBase
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21844892	FlyBase

Biological Process GO Annotation	Evidence	References	Source
involved in Bolwig's organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10704398	FlyBase
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18987629	FlyBase
involved in blastoderm segmentation	IMP IMP: Inferred from mutant phenotype	8700230	FlyBase
involved in compound eye morphogenesis	IMP IMP: Inferred from mutant phenotype	16651542	FlyBase
involved in eye-antennal disc morphogenesis	IGI IGI: Inferred from genetic interaction	11934850	FlyBase
involved in follicle cell of egg chamber development	IGI IGI: Inferred from genetic interaction	29093440	FlyBase
involved in follicle cell of egg chamber development	IMP IMP: Inferred from mutant phenotype	16256740	FlyBase
involved in imaginal disc-derived wing morphogenesis	IMP IMP: Inferred from mutant phenotype	20844016	FlyBase
involved in mucosal immune response	IMP IMP: Inferred from mutant phenotype	25639794	FlyBase
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15809036	FlyBase
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	35037619	FlyBase
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17658259	FlyBase
involved in regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	23018595	FlyBase
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	11279500	FlyBase
involved in regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	28619819	FlyBase
involved in segment polarity determination	IMP IMP: Inferred from mutant phenotype	8700230	FlyBase
involved in smoothened signaling pathway	IDA IDA: Inferred from direct assay	14636583	FlyBase
involved in smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16386907	FlyBase
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	8898207	FlyBase
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16256740	FlyBase

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with axon	IDA IDA: Inferred from direct assay	24768000	FlyBase
located in cilium	IDA IDA: Inferred from direct assay	24768000	FlyBase
located in dendrite	IDA IDA: Inferred from direct assay	24768000	FlyBase
located in neuronal cell body	IDA IDA: Inferred from direct assay	24768000	FlyBase
located in plasma membrane	IDA IDA: Inferred from direct assay	10966113	FlyBase
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	19850026	FlyBase

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

smo Protein Structure

CRD_SMO

7tmF_SMO_homolog

0
200
400
600
800
1036 a.a.

Protein Preferred Names	Protein Names
smoothened	CG11561-PA smo-PA smooth smoothene

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16582A	Sonidegib	Antagonist	99.98%	Yes
HY-16391	Glasdegib	Inhibitor	99.65%	Yes
HY-B0603	Fluticasone	Agonist	98.70%	Yes
HY-16582	Sonidegib diphosphate	Antagonist	99.97%	Yes
HY-B0877	Halcinonide	Agonist	98.29%	Unkown
HY-16391A	Glasdegib maleate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13654	IPI-269609	Inhibitor	/	Phase 4
HY-16587	Saridegib	Inhibitor	99.95%	Phase 3
HY-13242	Taladegib	Inhibitor	99.92%	Phase 2
HY-13809	BMS-833923	Inhibitor	99.82%	Phase 2
HY-18636	LEQ506	Inhibitor	98.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-17024	Cyclopamine	Inhibitor	99.97%	Unkown
HY-15108	Purmorphamine	Activator	99.94%	Unkown
HY-100224	SANT-1	Antagonist	99.87%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.91%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	98.23%	Unkown
HY-15483	DY131	Inhibitor	99.72%	Unkown
HY-100535	KAAD-Cyclopamine	Antagonist	≥96.0%	Unkown
HY-12316	20(S)-Hydroxycholesterol	Activator	99.63%	Unkown
HY-15108G	Purmorphamine (GMP)	Agonist	/	Unkown
HY-N0836	Jervine	Inhibitor	99.28%	Unkown
HY-12317	GSA-10	Agonist	≥98.0%	Unkown
HY-13459	PF-5274857	Antagonist	99.31%	Unkown
HY-15412	HhAntag		99.40%	Unkown
HY-N0247	Saikosaponin B1	Inhibitor	99.42%	Unkown
HY-151115	JNJ-1289	Inhibitor	98.06%	Unkown
HY-12848R	SAG (Standard)	Agonist	99.56%	Unkown
HY-137115	BODIPY-Cyclopamine		98.91%	Unkown
HY-113965	CUR61414	Inhibitor	99.04%	Unkown
HY-115566	S1PL-IN-1	Antagonist	99.9%	Unkown
HY-100036	MK-4101	Antagonist	99.16%	Unkown
HY-117407	ALLO-2	Antagonist	99.72%	Unkown
HY-18287	MRT-83	Antagonist	99.27%	Unkown
HY-18287A	MRT-83 hydrochloride	Antagonist	99.60%	Unkown
HY-100224G	SANT-1 (GMP)	Antagonist	/	Unkown
HY-120499	AZD8542	Antagonist	99.49%	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-108507	MRT-10	Antagonist	98.99%	Unkown
HY-108508	SMANT hydrochloride	Inhibitor	99.90%	Unkown
HY-12316R	20(S)-Hydroxycholesterol (Standard)	Activator	98.69%	Unkown
HY-13459A	PF-5274857 hydrochloride	Antagonist	/	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-150567	SMO-IN-3	Inhibitor	/	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-177291	LAB687	Antagonist	/	Unkown
HY-16391S1	Glasdegib-d4	Inhibitor	/	Unkown
HY-183335	SMO-IN-6	Inhibitor	/	Unkown
HY-148440	RL-0070933	Modulator	/	Unkown
HY-162273	Antibacterial agent 189		/	Unkown
HY-162372	Hedgehog IN-6	Inhibitor	/	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-16391B	Glasdegib hydrochloride	Inhibitor	/	Unkown
HY-159893	SMO-IN-5	Inhibitor	/	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-131016	IHR-Cy3	Antagonist	/	Unkown
HY-110326	Smo antagonist M25	Antagonist	/	Unkown
HY-147670	TPB15	Inhibitor	/	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-145918	MRT-14	Antagonist	98.91%	Unkown
HY-16587A	Saridegib hydrochloride	Inhibitor	/	Unkown
HY-123752	MS-0022	Antagonist	/	Unkown
HY-150564	SMO-IN-2	Inhibitor	98.12%	Unkown
HY-117903A	MRT-92	Antagonist	/	Unkown
HY-133974	7-keto-25-Hydroxycholesterol	Activator	/	Unkown
HY-12848G	SAG (GMP)	Agonist	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990418	Anti-FZD7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	smo	NCBI	NCBI:6608